Kidney diseases Flashcards
what are the functions of the kidneys
- regulates water balance
- electrolyte regulation
- regulated acid-base
- removes waste
- produced hormones
BUN
bi-product of preotein metabolism
creatinine
by product of muscle metabolism
GFR
rate at which blood passes through the glomeruli
anuria
no urine output or less than 100ml in 24 hours
oliguria
less than 400 ml of urine in 24 hours
poluria
more than 2.5L of urine in 24 hours
pathophys for acute kindey injury
abrupt decline in kindey fcxn.
can be reversed if treated fast enough
what does the RIFLE classification look at
- urine output
- GFR
- creatinine
what are the main complications when kidneys begin to fail
- fluid volume excess
- hyperkalemia
- hematological disorders
- neuro disorders
- metabolic acidosis
- hyponatremia
- decrease calcium and increase phosphate
- waste products accumulate
oliguric phase of kidney injury
- BUN and creatinine rise while GFR fals
- main concerns are fluid overload, electrolyte imbalances and acidosis (H+ accumulation)
diuretic phase
- damaged tubules are recovering their functions
- excessive urination, hypovolemia and hypotension
- GFR increases and BUN and creatinine begin to normalize
recovery phase of AKI
- normalisation of fluid and electrolyte imbalances
- GFR becomes normal to near normal
prerenal causes of AKI
- decreased renal blood flow such as renal hypoperfusion whihc causes them to become ischemic
- no structural damage occurs unless untreated
intra-renal causes of AKI
- structural damage to the glumeruli or tubules
- recvoery is less likely and prolonged
post-renal causes of AKI
- mechanical obstruction of urine flow
what are the multiple causes of ATN
- decreased blood flow
- injury or trauma to muscles
- low blood pressure lasting longer than 30 minutes
- recent major surgery
- septic shock
- liver and kidney disease casued by diabetes
- medications that are toxic to th kidneys (aminoglycosides, antibitoics and antifungals)
Most important clinical monitoring for AKI
- MAP at least 70 mmhg or larger
- urine output with a fluctuation of normal 5% or less
what is the focused assessment for patient coming in with kindey injury
- nausea and vomiting
- FATIGUE OR LETHARGY
- neuro changes
- urine output or changes
- ## medications or recent infections
^physical assessment for kidney injury
- vitals, ins and outs, bruises
- edema, JVD
- crackles wheezing or breath sounds
- heart murmursor rubs
what are labs and test that should be run for kidney injury
- urineanalysis
- bloods
- renal ultrasounds
- kidney scan
- CT - caution for contrast since kidney might have trouble excreting it
how would you treat FVD with AKI
- 1-3L of crystalloids
how do you treat FVE with AKI
- IV lasix
what is the management for acute hyperkalemia with AKI
- calcium gluconate
- IV glucose
- insulin
- B2 adrenergic agonist