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Blood Bank Quiz 2 > Kidd - Bennet > Flashcards

Kidd - Bennet Flashcards

1
Q

Kidd blood group “JK”, discovered in 1951, was detected in the ________ of ___________ who had an infant with HDFN

A

serum of Mrs. Kidd

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2
Q

The antibodies for Kidd was detected in the serum of the mother who had an infant with ________

A

HDFN

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3
Q

Antibody name for Kidd blood group

A

Anti-Jk^a

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4
Q

In what year wa the atithetical partner of Jk^a was found?

A

1953

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5
Q

High prevalence Kidd antigen;
This antigen is present on RBCs positive for __________

A

Jk3;
Jka and Jkb

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6
Q

Significant cause of Hemolytic transfusion reactions

A

Kidd antibodies

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7
Q

These antigens are found on most populations, both well devleoped at birth

A

Kidd antigens

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8
Q

Jka can be detected of fetal RBCs at _______ weeks gestation while Jkb can be detected at _____ weeks gestation

A

11; 7

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9
Q

Kidd antigens (Jka and Jkb) are resistant to _____________ (2) and are not affected by ______________ (3)

A

ficin and or papain;
chloroquine, dithiothreitol, and glycine-acid EDTA

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10
Q

The antigens are not found on other blood cells

A

Kidd antigens

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11
Q

Location of Jk gene

A

Chromosome 18q12.3

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12
Q

Enumerate all Kidd Phenotypes (4)

A

Jk (a+b-)
Jk (a+b+)
Jk (a-b+)
Jk (a-b-)

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13
Q

Jk (a-b-) is referred to as ______ that lacks _____ antigens

A

null; 3

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14
Q

Common in filipinos, japanese, chinese, and indonesians

A

Jk (a-b-)

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15
Q

Jk (a-b-) resists lysis in

A

2M Urea

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16
Q

Jk (a-b-) is associated with a dominant gene called _______.

A

In (Jk) gene

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17
Q

Weak and demonstrates dosage. It reacts strongly with RBCs with double dose antigen.

A

Kidd antibodies: anti-Jka and anti-Jkb

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18
Q

Found in combination with other antibodies

A

Kidd antibodies

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19
Q

Stimulated by pregnancy and transfusion

A

Kidd Antibodies (and Kell Antibodies)

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20
Q

Kidd antibodie reactivity can be enhanced by using

A

LISS or PEG

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21
Q

Titers for this antibody declines in-vivo. It may go undetectable few weeks after detection.

A

Kidd Antibodies (Anti-Jka and anti-Jkb)

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22
Q

Known to be notorious for its danger in causing severe/fatal delayed HTR and some HDFN

A

Kidd Antibodies

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23
Q

Kidd antibody that is and IgG and reacts at AHG phase.
It is associated with both immediate and delayed HTRs and mild HDFN

A

Anti-Jk3

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24
Q

Discovered I Blood Group

A

Weiner and his coworkers

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25
Q

The antigen for that agglutinin in I Blood Group “I” is for

A

individuality

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26
Q

Discovered Anti-I

A

Marsh and Jenkins

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27
Q

1) A linear carbohydrate
2) A branched carbohydrate

A

1) i
2) I

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28
Q

These are formed due to activity of glycosyl transferases

A

I and i

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29
Q

True or False. I and i are both high-prevalence antigens

A

True

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30
Q

Relationship of I and i antigens

A

reciprocal relationship

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31
Q

Which among the I blood group antigens decreases during the first 18 months of life?

A

i

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32
Q

1) Infant RBCs are rich in
2) Adult RBCs are rich in

A

1) i
2) I

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33
Q

I is undetectable in

A

Infant RBCs

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34
Q

i is trace in

A

Adult RBCs

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35
Q

Adults that retain their i antigen

A

Adult-i

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36
Q

More and more adult i are present in adult RBCs compared to ________.

A

cord blood RBCs

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37
Q

I and i antigens are enhance by; resistant to:

A

Enhanced by Ficin and Papain
Resistant to Dithiothreitol and Glycine-acid EDTA

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38
Q

Precursor for the synthesis of ABO and Lewis antigens

A

I and i antigens

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39
Q

Defines the “i” antigen activity

A

at least two repeating N-acetyllactosamine units in linear form

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40
Q

Associated with branched form of “i” antigen

A

I antigen activity

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41
Q

Encodes the N-acetylglucosaminyltransferase that adds N-acetylglucosamine (G1cNAc) to form the branches

A

IGnt gene (GCNT2)

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42
Q

Found on chromsome 6p24

A

IGnt gene (GCNT2)

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43
Q

This can alter the expression of I and i antigens

A

disease

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44
Q

Conditions where i antigen expression is increased (AHM STS PC)

A

Acute Leukemia
Hypoplastic anemia
Megaloblastic anemia

Sideroblastic anemia
Thalassemia
Sickle Cell disease

Paroxysmal nocturnal hemoglobinuria
Chronic hemolytic anemia

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45
Q

Sources of I and i antigen (MLP and SSH AU O)

A

Membranes of leukocytes and platelets (same with Lewis: lymphocytes and platelets)

Serum, saliva, human milk, amniotic fluid, urine, and ovarian cyst fluid

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46
Q

True or False. I and i secretions do not correlate with RBC expression and are thought to develop under the same genetic control.

A

False. I and i secretions do not correlate with RBC expression and are thought to develop under SEPARATE genetic control.

47
Q

Common autoantibody found virtually in all sera

A

Anti-I

48
Q

A type of antibody that is not associated with in-vivo RBC destruction

A

Benign antibody

49
Q
  • Weak, naturally occuring, saline-reactive IgM agglutinin
  • Stronger antibodies agglutinate test cells at room temperature and binds complement
A

Anti-I

50
Q

A benign antibody

A

Anti-I

51
Q

Reagent used to detect Anti-I

A

polyspecific AHG reagent

52
Q

Anti-I is tested at ___C with enzymee treated RBCs

A

4C

53
Q

Enhances anti-I reactivity

A

incubating in cold

54
Q

Antibodies with strong agglutination to adult RBCs but weak with cord blood or adult i RBCs

A

Anti-I

55
Q

Microorganisms carrying I-like antigen

A

M. pneumoniae

56
Q

A strong IgM agglutinin with higher titers and a broad thermal range of activity

A

Pathogenic Autoanti-I

57
Q

Thermal range for pathogenic autoanti-I

A

30-32C

58
Q

In pathogenic autoanti-I, when the circulation cools in resonse to low ambient temperatures, the antibodies attach in vivo and cause (3)

A

autoagglutination, vascular occlusion, or hemolytic anemia

59
Q

Antibody that reacts with adult and cord RBCs at room temperature and at 4C

A

Pathogenic autoanti-I

60
Q

Exists as IgG or IgM in the serum of most Adult-i individuals

A

alloanti-I

61
Q

A rare antibody that gives strong reactions with cord RBCs and adult-i RBCS

A

autoanti-i

62
Q

Not common in healthy indivduals

A

anti-i

63
Q

Some are associated with infectious mononucleosis and lymphoproliferative disorders

A

anti-i

64
Q

IgG types are rare but are associated with HDFN

A

Anti-i

65
Q

Enumerate all the antigens in P blood group

A

P, P1, Pk, and Luke

66
Q

These antigens are not considered as a single blood group system

A

P, P1, Pk, and luke

67
Q

Antigens assigned to P1Pk blood group system (003)

A

P1 and Pk

68
Q

Antigens assigned to Globoside blood group system (028)

A

P and PX2

69
Q

Antigens assigned to Globoside collectio (209)

A

LKE

70
Q

P blood group was introduced by Landsteiner and Levine via injection of human RBCs to __________ to produce new antibodies

A

rabbits

71
Q

This finding divided the human RBCs then into P+ and P-

A

Anti-P

72
Q

Anti-Tj^a is now known as

A

anti-PP1Pk

73
Q

Present names of P+, P-, andrare P null

A

P1, P2, and p respectively

74
Q

The antigen is expressed on all RBCs except those of very rare p phenotypes.
Not readily detected unless P is absent

A

antigen Pk

75
Q

P blood group common phenotypes

A

P1 and P2

76
Q

Describes RBCs that react with Anti-P1 and Anti-P

A

P1

77
Q

Describes RBCs that do not react with Anti-P1 but reacts with Anti-P-

A

P2

78
Q

Rare phenotypes of the P blood group

A

p, P1k, and P2k

79
Q

This phenotype do not react with Anti P1, Anti-P, or Anti-Pk

A

p

80
Q

p phenotypes are common in what countries?

A

Japan, north sweden, and ohio

81
Q

Reacts with Anti-P1 and Anti-Pk but not with Anti-P

A

P1k phenotypes

82
Q

Reacts with Anti-Pk but not with Anti-P1 or Anti-P

A

Pk2 phenotypes

83
Q

P Blood group antigens are synthesized by

A

glycosyltransferases

84
Q

Adds sugar to a precursor substance

A

glycosyltransferases

85
Q

Precursor subtance to P1 is also precursor for type 2H chains that carry ________ antigens

A

ABH

86
Q

True or False. Genes responsible for the formation of P1 and ABH antigens are dependent.

A

False. Independent

87
Q

P, P1, and Pk can be found on

A

RBCs and WBCs

88
Q

Can be found on platelets, epithelial cells, and fibroblasts

A

P

89
Q

P and Pk in plasma, in hydatid cyst fluid

A

plasma: glycosphingolipids
hydatid cyst fluid: glycoproteins

90
Q

Poorly expressed at birth and may take 7 years for full expression

A

P1 antigen

91
Q

P1 antigen strength varies from

A

inheritance and race

92
Q

Differences among P1+ individuals may be controlled genetically or via

A

homozygous or heterozygous inheritance

93
Q

Deteriorates rapidly on storage

A

P1 antigen

94
Q

This led to the discovert of P1 and Pk susbtance in hydatid cyst fluid

A

Anti-P1 in two P1-individuals with Echinococcus granulosus worms

95
Q

Strong antibodies to P1 have been found in patients with

A

Fascioliasis (bovine liver fluke disease)

96
Q

In P antigen synthesis :

1) common precursor
2) Carries out Pk synthesis
3) Carries out P synthesis

A

1) Lactosylceramide
2) 4-a-galactosyltransferase
3) 3-B-N-acetylgalactosaminyltransferase

97
Q

encodes the 4-a-galactosyltransferase

A

P1Pk gene (A4GALT)

98
Q

encodes the 3-B-N-acetylgalactosaminyltransferase

A

Globoside gene (B3GALNT1)

99
Q

Antibodies for Luke Antigens, described by Tipett and Colleagues, was found in the serum of a ____________ patient in 1965

A

Hodgkin’s lymphoma

100
Q

Luke (-) phenotypes

A

p and Pk

101
Q

Percentage:

Luke (+)
Luke (-)
Luke (w)

A

84%
2%
12%

102
Q

Weak, cold-reactive saline agglutinin

A

Anti-P1

103
Q

May cause in-vivo RBC destruction, immediate or delayed HTRs (P Antibodies)

A

Anti-P1

104
Q

Anti-PP1Pk was formerly

A

Anti-Tj^a

105
Q

Condition of Mrs. Jay, the p-individual where Anti-PP1Pk was first discovered

A

adenocarcinoma of the stomach

106
Q

Anti-PP1Pk possesses these properties that may have helped prevent metastatic growth post surgery of Mrs. Jay who had adenocarcinoma of the stomach

A

cytotoxic properties

107
Q

Produced by p individuals early in life without RBC sensitizatio and reacts with all RBCs except those of the p phenotype

A

Anti-PP1Pk

108
Q

1) Components of Anti-PP1PK which are IgG and IgM
2) components are separated by

A

Anti P, Anti-P1, and Anti-Pk;
Adsorption

109
Q

Reacts over a wide thermal range and bind complement

A

Anti-PP1PK

110
Q

Can cause HTRs and HDFN

A

Anti-PP1Pk

111
Q

A component of anti-PP1Pk in p individuals

A

Alloanti-P

112
Q

HLA detectable on RBCs

1) Bg^a
2) Bg^b
3) Bg^c

A

HLA-B7
HLA-B17
HLA-A28

113
Q

Importance of studying other blood group system (4)

A

Avoid HTR and HDFN
Avoid confusion brought up by insignificant antibodies
Avoid mistyping
Properly find and identify potential donors to rare blood group patients

Blood Bank Quiz 2 (2 decks)

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