Key translocations

Question 1

What is the key translocation associated with APML

Answer 1

t(15;17) - PML-RARA

Question 2

What is the key translocation associated with CML

Answer 2

t(9;22) - BCR-ABL

Question 3

What is the key translocation associated with Burkitt-Lymphoma

Answer 3

t(8;14) - MYC-Ig

Question 4

What is the key translocation associated with Ewings Sarcoma

Answer 4

t(11;22) - EWS/Fli1

Question 5

What is the key translocation associated with Infant B-ALL

Answer 5

t(4;11) - MLL rearrangement

Question 6

What is the key translocation associated with a GOOD prognosis in B-ALL

Answer 6

t(12;21) - ETV6/RUNX1

Question 7

what translocation is associated with Synovial Sarcoma

Answer 7

t(X;18) - SYT/SSX

Question 8

what is the key translocation in Follicular lymphoma

Answer 8

t(14;18) - BCL2 / Ig

Question 9

What are the 3 most common translocations in AML

Answer 9

> APML: t(15;17) - PML/RARA
AML: t(8;21) - RUNX1 / RUNX1T1
inv(16)(p13q22) - CBFB-MYH11

note: both RUNX1 and CBFC make up the CBF classed as a class 2 mutation in leukaemia