Key translocations Flashcards

1
Q

What is the key translocation associated with APML

A

t(15;17) - PML-RARA

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2
Q

What is the key translocation associated with CML

A

t(9;22) - BCR-ABL

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3
Q

What is the key translocation associated with Burkitt-Lymphoma

A

t(8;14) - MYC-Ig

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4
Q

What is the key translocation associated with Ewings Sarcoma

A

t(11;22) - EWS/Fli1

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5
Q

What is the key translocation associated with Infant B-ALL

A

t(4;11) - MLL rearrangement

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6
Q

What is the key translocation associated with a GOOD prognosis in B-ALL

A

t(12;21) - ETV6/RUNX1

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7
Q

what translocation is associated with Synovial Sarcoma

A

t(X;18) - SYT/SSX

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8
Q

what is the key translocation in Follicular lymphoma

A

t(14;18) - BCL2 / Ig

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9
Q

What are the 3 most common translocations in AML

A

> APML: t(15;17) - PML/RARA
AML: t(8;21) - RUNX1 / RUNX1T1
inv(16)(p13q22) - CBFB-MYH11

note: both RUNX1 and CBFC make up the CBF classed as a class 2 mutation in leukaemia

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