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MOLECULAR AND CELLULAR NEUROBIOLOGY > Key Terms - Synaptic cell adhesion molecules > Flashcards

Key Terms - Synaptic cell adhesion molecules Flashcards

L2

1
Q

SCAMS

A
  • Synaptic cell adhesion molecules
  • Transmembrane proteins which are localised at the synapse and interact with each other across the synapse
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2
Q

Definition of

Synaptic plasticity

A

The capacity of synapses to adjust their properties in response to previous activity

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2
Q

Explain

**Establishment **

A

*1rst stage of synapse formation
* The pre-and postsynaptic neurons are recognized by possibly the interaction between SCAMS

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3
Q

Explain

Assembly

A

*2nd stage in synapse formation
*Recruitment of synaptic vesicles, active zones and postsynaptic density.

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4
Q

Explain

Specification

A

*3rd stage in synapse formation
* Organisation of the molecular components of the synapse which results in the functionality of the synapse

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5
Q

Explain

Plasticity

A
  • 4rd stage in synapse formation
  • SCAMs may contribute to structural and functional synaptic plasticity in activity-dependent events
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6
Q

The adhesive function of SCAMs is based on a limited number of extracellular domains, including Ig domains. Explain

A

*Immunoglobulin domains most frequently bind to other Ig domains.
* Most SCAMs containing Ig domains, also contain FnIII domains

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7
Q

The adhesive function of SCAMs is based on a limited number of extracellular domains, including Cadherin domains. Explain

A
  • Always occur in multiple copies connected by a linker that binds 2-3 calcium ions.
  • Therefore cadherin-mediated interactions are calcium-dependent and often homophilic
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8
Q

What are neurexins

A

Presynaptic single-pass membrane proteins with a large extracellular sequence an a short cytoplasmic tail

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9
Q

What are neuroligins

A

Postsynaptic single-pass membrane proteins

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10
Q

Extracellularly, what does alpha-neurexins contain (structure-wise) ?

A
  • 6 LNS domains
  • 3 intersperse EGF-like domains
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11
Q

Extracellularly, what does beta-neurexins contain (structure-wise) ?

A
  • 1 LNS domains
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12
Q

Intracellularly, what does alpha-neurexins & beta-neurexins contain? (structure-wise)

A
  • PDZ-domain-binding sequence
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13
Q

The PDZ-domain-binding sequence, what does it bind

A

It binds to intracellular proteins, e.g. CASK & protein 4.1

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14
Q

How do Neurexins and Neuroligins interact?

A

Neurexins bind to Neuroligins to form trans-synaptic cell adhesion complexes, using the 6th LNS domain of the alpha-neurexin and the single LNS domain of beta-neurexin

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15
Q

What are the vital functions of neurexin-neuroligin interactions?

A

They have a vital function in organising the synapses, e.g. recruitment of calcium channels and components or the release machinery to presynaptic active zones

MOLECULAR AND CELLULAR NEUROBIOLOGY (7 decks)

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