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1
Q

CD56

A

NK cells

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2
Q

CD38/138

A

plasma cells

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3
Q

influenza virus tx

A

M2 channel inhibitors, NA inhibitors, vaccines

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4
Q

DHFR inhibitors

A
  • antifungal
  • inhibit folate (and thus pyrimidine) synthesis
  • ex = TMP-SMX
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5
Q

CD19

A

B cells

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6
Q

TNF-alpha

A

pro-inflammatory

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7
Q

azoles

A
  • antifungal
  • inhibit ergosterol synthesis via inhibition of cyp p450
  • ex = fluconazole, itraconazole
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8
Q

chagas disease dx

A

amastigotes in cardiac tissue or serology

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9
Q

leishmaniasis dx

A

skin biopsy or culture

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10
Q

allylamines

A
  • antifungal
  • inhibit squalene epoxidase, an earlier step in ergosterol synthesis
  • ex = terbinafine
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11
Q

CD80/86

A
  • B7 on APC’s

- Bind CD28 and activate T cells

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12
Q

IL-8

A

recruits neutrophils

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13
Q

norovirus tx

A

supportive

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14
Q

leishmaniasis clinical manifestiations

A
  • visceral = kala-azar
  • cutaneous = non-healing ulcer
  • mucotaneous
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15
Q

IL-4

A
  • promotes B cell growth and class switching to IgE and IgG

- promotes Th2 differentiation and inhibits Th1 differentiation

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16
Q

rotavirus tx

A

oral rehydration, oral vaccine

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17
Q

IL-13

A

activates eosinophils

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18
Q

TGF-beta

A

anti-inflammatory

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19
Q

CMV tx

A

(val)ganciclovir, foscarnet, cidofovir

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20
Q

CD28

A
  • co-stimulatory T cell protein that binds APC B7 (CD80/86)

- inhibited by CTLA-4

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21
Q

norovirus dx

A

PCR

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22
Q

TMP-SMX class

A

DHFR inhibitor

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23
Q

rhinovirus dx

24
Q

fluconazole class

25
Q

nematode

26
Q

human metapneumovirus dx

27
Q

cestode

A

tapeworm (echinococcus)

28
Q

caspofungin class

A

echinocandin

29
Q

trematode

A

flatworm/fluke (schistosoma)

30
Q

CD8

A

cytotoxic T cells

31
Q

CD4

A

helper T cells

32
Q

IL-17

A
  • promotes neutrophils

- produced by Th17 cells

33
Q

IFN-gamma

A
  • stimulates macrophages
  • increases MHC class I and II expression
  • promotes Th1 and inhibits Th2
34
Q

which is more severe: T. b. rhodiense (East African) or T. b. gambiense (West African?

A

gambiense => meningencephalitis

rhodiense => fever, headache, lymphadenopathy

35
Q

IL-10

A

anti-inflammatory

36
Q

HHV-8 tx

A

in vitro susceptibility to GCV, foscarnet, and cidofovir but none are effective

37
Q

CD3

38
Q

IL-2

A

promotes T cells growth and activation; autocrine function

39
Q

IL-5

A
  • differentiation/activation of eosinophils

- IgA class switching

40
Q

RSV dx

A

antigen detection, RT-PCR

41
Q

IL-1

A

pro-inflammatory, pyrogen

42
Q

terbinafine class

A

allylamine

43
Q

IL-6

A

pro-inflammatory, pyrogen

44
Q

CD20

A

B cells; target of rituximab

45
Q

CD40L

A
  • expressed on T cells after activation

- binds CD40 on B cells/APCs

46
Q

echinocandins

A
  • antifungal
  • inhibit cell wall glucan synthesis and impair cell wall stress tolerance
  • ex = caspofungin
47
Q

IL-12

A
  • T cell growth factor

- Stimulates Th1

48
Q

african sleeping sickness dx

A

trypomastigotes in blood smear or CSF

49
Q

schistosoma life cycle (basic)

A

cercarieae in fresh water penetrate skin => travel upstream through portal circulation in liver => adults migrate to bowel/bladder to lay eggs => excretion of eggs into water through feces/urine => eggs hatch and penetrate snails where they develop into cercariae again

50
Q

RSV tx

A

palivizumab prophylaxis, nebulized hypertonic saline

51
Q

malaria dx

A
  • history
  • rapid antigen testing
  • blood smear
52
Q

amphotericin B/nystatin class

53
Q

polyenes

A
  • antifungal
  • bind ergosterol and disrupt cell membrane
  • ex = amphotericin B, nystatin
54
Q

CMV dx

A

Owl’s eye inclusions, qPCR

55
Q

cytokines produced in malaria infection

A

TNF, IFN-gamma, IL-1

56
Q

influenza virus dx

A

rapid antigen test, RT-PCR

Foundations III (26 decks)

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