key cards Flashcards
1
Q
CD56
A
NK cells
2
Q
CD38/138
A
plasma cells
3
Q
influenza virus tx
A
M2 channel inhibitors, NA inhibitors, vaccines
4
Q
DHFR inhibitors
A
- antifungal
- inhibit folate (and thus pyrimidine) synthesis
- ex = TMP-SMX
5
Q
CD19
A
B cells
6
Q
TNF-alpha
A
pro-inflammatory
7
Q
azoles
A
- antifungal
- inhibit ergosterol synthesis via inhibition of cyp p450
- ex = fluconazole, itraconazole
8
Q
chagas disease dx
A
amastigotes in cardiac tissue or serology
9
Q
leishmaniasis dx
A
skin biopsy or culture
10
Q
allylamines
A
- antifungal
- inhibit squalene epoxidase, an earlier step in ergosterol synthesis
- ex = terbinafine
11
Q
CD80/86
A
- B7 on APC’s
- Bind CD28 and activate T cells
12
Q
IL-8
A
recruits neutrophils
13
Q
norovirus tx
A
supportive
14
Q
leishmaniasis clinical manifestiations
A
- visceral = kala-azar
- cutaneous = non-healing ulcer
- mucotaneous
15
Q
IL-4
A
- promotes B cell growth and class switching to IgE and IgG
- promotes Th2 differentiation and inhibits Th1 differentiation
16
Q
rotavirus tx
A
oral rehydration, oral vaccine
17
Q
IL-13
A
activates eosinophils
18
Q
TGF-beta
A
anti-inflammatory
19
Q
CMV tx
A
(val)ganciclovir, foscarnet, cidofovir
20
Q
CD28
A
- co-stimulatory T cell protein that binds APC B7 (CD80/86)
- inhibited by CTLA-4
21
Q
norovirus dx
A
PCR
22
Q
TMP-SMX class
A
DHFR inhibitor
23
Q
rhinovirus dx
A
PCR
24
Q
fluconazole class
A
azole
25
nematode
roundworm
26
human metapneumovirus dx
RT-PCR
27
cestode
tapeworm (echinococcus)
28
caspofungin class
echinocandin
29
trematode
flatworm/fluke (schistosoma)
30
CD8
cytotoxic T cells
31
CD4
helper T cells
32
IL-17
- promotes neutrophils
| - produced by Th17 cells
33
IFN-gamma
- stimulates macrophages
- increases MHC class I and II expression
- promotes Th1 and inhibits Th2
34
which is more severe: T. b. rhodiense (East African) or T. b. gambiense (West African?
gambiense => meningencephalitis
rhodiense => fever, headache, lymphadenopathy
35
IL-10
anti-inflammatory
36
HHV-8 tx
in vitro susceptibility to GCV, foscarnet, and cidofovir but none are effective
37
CD3
T cells
38
IL-2
promotes T cells growth and activation; autocrine function
39
IL-5
- differentiation/activation of eosinophils
| - IgA class switching
40
RSV dx
antigen detection, RT-PCR
41
IL-1
pro-inflammatory, pyrogen
42
terbinafine class
allylamine
43
IL-6
pro-inflammatory, pyrogen
44
CD20
B cells; target of rituximab
45
CD40L
- expressed on T cells after activation
| - binds CD40 on B cells/APCs
46
echinocandins
- antifungal
- inhibit cell wall glucan synthesis and impair cell wall stress tolerance
- ex = caspofungin
47
IL-12
- T cell growth factor
| - Stimulates Th1
48
african sleeping sickness dx
trypomastigotes in blood smear or CSF
49
schistosoma life cycle (basic)
cercarieae in fresh water penetrate skin => travel upstream through portal circulation in liver => adults migrate to bowel/bladder to lay eggs => excretion of eggs into water through feces/urine => eggs hatch and penetrate snails where they develop into cercariae again
50
RSV tx
palivizumab prophylaxis, nebulized hypertonic saline
51
malaria dx
- history
- rapid antigen testing
- blood smear
52
amphotericin B/nystatin class
polyene
53
polyenes
- antifungal
- bind ergosterol and disrupt cell membrane
- ex = amphotericin B, nystatin
54
CMV dx
Owl's eye inclusions, qPCR
55
cytokines produced in malaria infection
TNF, IFN-gamma, IL-1
56
influenza virus dx
rapid antigen test, RT-PCR
