immuno names to remember Flashcards
IL-2
promotes T cell growth and activation; can act in an autocrine fashion to allow clonal growth/proliferation of antigen specific T cells
CD3
all T cells
CD4
helper T cells
CD8
cytotoxic T cells
CD19
all B cells; component of BCR complex
CD56
all NK cells
CD28
costimulatory protein on T cells (2nd signal)
C1
recognizes antigen-antibody complexes in the classic pathway of complement activation
C3 convertase
associates with pathogen cell membrane and cleaves/activates other complement proteins
C3a
triggers mast cells to degranulate and release histamine (anaphylatoxin)
C5a
- triggers mast cells to degranulate and release histamine (anaphylatoxin)
- chemotactic for neutrophils
C3b
opsonin for phagocytosis
C5b + C6-C9
Form MAC
C1 esterase inhibitor
inhibits classical pathway of C3 convertase formation
CD55
decay accelerating factor, inhibits formation of C3 convertase
IL-10
anti-inflammatory cytokine produced by neutrophils and monocytes/macrophages
transforming growth factor beta (TGFB)
anti-inflammatory cytokine produced by neutrophils and monocytes/macrophages
IL-1
pro-inflammatory cytokine: pyrogen, induces acute phase response
IL-6
pro-inflammatory cytokine: pyrogen, induces acute phase response
IL-8
pro-inflammatory cytokine: recruits neutrophils
TNFa
pro-inflammatory cytokine: increases cyclo-oxygenase
TNFB
similar to TNFa (pro-inflammatory cytokine: increases cyclo-oxygenase)
interferons (a and B)
antiviral
CD79a and CD79b
- B cell receptor associated proteins (IgAlpha and IgBeta)
- antigen binding => cross-linking => phosphorylation of ITAMs => downstream signaling
CD20
B cell surface
CD21
Complement receptor (CR2) that binds complement component C3d in association with antigen to enhance the B cell response
CD40
co-stimulatory molecule on B cell surface that binds CD40L on CD4+ helper T cells to provide a second B cell signal => class switching, affinity maturation, differentiation1
CD38
plasma cell surface
CD138
plasma cell surface
IL-4
- promotes B cell growth
- promotes IgE/IgG class switching
- promotes differentiation of Th2 CD4+ T cells and inhibits differentiation of Th1 CD4+ T cells
IL-5
- differentiation and activation of eosinophils
- IgA class switching
IL-12
- T cell growth factor
- stimulates Th1 CD4+ cells
IL-13
activates eosinophils
IL-17
promotes neutrophilic inflammation
IFN-g
- stimulates phagocytosis by macrophages
- increases expression of MHC class I and II
- promotes Th1 and inhibits Th2 CD4+ response
IL-12 and IFN-g loop
APC’s produce IL-12 which drives CD4+ Th1 cells
CD4+ Th1 cells produce IFN-g
IFN-g drives CD8+ cells, NK cells, and APC’s
APC’s produce IL-12…
*mycobacterial infection
