immuno names to remember

Question 1

IL-2

Answer 1

promotes T cell growth and activation; can act in an autocrine fashion to allow clonal growth/proliferation of antigen specific T cells

Question 2

CD3

Answer 2

all T cells

Question 3

CD4

Answer 3

helper T cells

Question 4

CD8

Answer 4

cytotoxic T cells

Question 5

CD19

Answer 5

all B cells; component of BCR complex

Question 6

CD56

Answer 6

all NK cells

Question 7

CD28

Answer 7

costimulatory protein on T cells (2nd signal)

Question 8

C1

Answer 8

recognizes antigen-antibody complexes in the classic pathway of complement activation

Question 9

C3 convertase

Answer 9

associates with pathogen cell membrane and cleaves/activates other complement proteins

Question 10

C3a

Answer 10

triggers mast cells to degranulate and release histamine (anaphylatoxin)

Question 11

C5a

Answer 11

• triggers mast cells to degranulate and release histamine (anaphylatoxin)
• chemotactic for neutrophils

Question 12

C3b

Answer 12

opsonin for phagocytosis

Question 13

C5b + C6-C9

Answer 13

Form MAC

Question 14

C1 esterase inhibitor

Answer 14

inhibits classical pathway of C3 convertase formation

Question 15

CD55

Answer 15

decay accelerating factor, inhibits formation of C3 convertase

Question 16

IL-10

Answer 16

anti-inflammatory cytokine produced by neutrophils and monocytes/macrophages

Question 17

transforming growth factor beta (TGFB)

Answer 17

anti-inflammatory cytokine produced by neutrophils and monocytes/macrophages

Question 18

IL-1

Answer 18

pro-inflammatory cytokine: pyrogen, induces acute phase response

Question 19

IL-6

Answer 19

pro-inflammatory cytokine: pyrogen, induces acute phase response

Question 20

IL-8

Answer 20

pro-inflammatory cytokine: recruits neutrophils

Question 21

TNFa

Answer 21

pro-inflammatory cytokine: increases cyclo-oxygenase

Question 22

TNFB

Answer 22

similar to TNFa (pro-inflammatory cytokine: increases cyclo-oxygenase)

Question 23

interferons (a and B)

Answer 23

antiviral

Question 24

CD79a and CD79b

Answer 24

• B cell receptor associated proteins (IgAlpha and IgBeta)

- antigen binding => cross-linking => phosphorylation of ITAMs => downstream signaling

Question 25

CD20

Answer 25

B cell surface

Question 26

CD21

Answer 26

Complement receptor (CR2) that binds complement component C3d in association with antigen to enhance the B cell response

Question 27

CD40

Answer 27

co-stimulatory molecule on B cell surface that binds CD40L on CD4+ helper T cells to provide a second B cell signal => class switching, affinity maturation, differentiation1

Question 28

CD38

Answer 28

plasma cell surface

Question 29

CD138

Answer 29

plasma cell surface

Question 30

IL-4

Answer 30

• promotes B cell growth
• promotes IgE/IgG class switching
• promotes differentiation of Th2 CD4+ T cells and inhibits differentiation of Th1 CD4+ T cells

Question 31

IL-5

Answer 31

• differentiation and activation of eosinophils

- IgA class switching

Question 32

IL-12

Answer 32

• T cell growth factor

- stimulates Th1 CD4+ cells

Question 33

IL-13

Answer 33

activates eosinophils

Question 34

IL-17

Answer 34

promotes neutrophilic inflammation

Question 35

IFN-g

Answer 35

• stimulates phagocytosis by macrophages
• increases expression of MHC class I and II
• promotes Th1 and inhibits Th2 CD4+ response

Question 36

IL-12 and IFN-g loop

Answer 36

APC’s produce IL-12 which drives CD4+ Th1 cells

CD4+ Th1 cells produce IFN-g

IFN-g drives CD8+ cells, NK cells, and APC’s

APC’s produce IL-12…

*mycobacterial infection