Kash (5 questions on test)

Question 1

Exogenous pathway

Answer 1

transports DIETARY lipids to the periphery and liver

Question 2

Endogenous Pathway

Answer 2

transports HEPATIC lipids to the periphery

Question 3

Largest lipoprotein

Answer 3

Chylomicron.

Question 4

Highest Cholesterol

Answer 4

LDL (60%)

Question 5

Hyperlipidemia

Answer 5

major cardiovascular risk factor that affects 25% of population. Cuases vessel damage due to oxidized LDL to form foam cells and lesions.

Question 6

Proatherogenic risk factors for developing CV

Answer 6

high LDL
High Total Cholesterol
high Cholesterol / HDL
Low HDL (can’t be too low)

Question 7

Statins

Answer 7

treat hyperlipidemia. NOT EFFECTIVE if LDL recepetor is dysfunctional. Inhibits HMG-CoA reductase (the RLS) that catalyzes Cholesterol synthesis. Liver has to get extra cholesterol from the blood instead.
Can cause HEPATOTOXICITY and MYOPATHY.