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Phpy 305 > Jadhav > Flashcards

Jadhav Flashcards

1
Q

Non selective COX inhibitors

A

NSAIDS - Aspirin & ibuprofen

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2
Q

Aspirin

A

NSAID (non selective COX-Inh.) irreversibly binds Cox I & II. inhibits pain in peripheral and CNS. Can cause GI EFECTS , decreased BLOOD COAGULATION, and decreased RENAL BLOOD FLOW (due to vasoconstrictors).

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3
Q

COX II inhibitor

A

Rofecoxib

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4
Q

Rofecoxib

A

NSAID selective COX II inhibitor. does NOT alter mucosal defence or platelet aggregation. BUT can cause Increased CLOTS and MI. TBX-A2 isn’t reduced which increases PLATELET STICKINESS. [withdrawn]

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5
Q

Acetaminophen

A 
Tylenol; lacks anti-inflammatory actions.  Less GI stress than Aspirin.  HEPATOTOXIC (10mg) Antedote: N-acetylcysteine.
* NO PERIPHERAL COX INHIBITION.
Strong Analgesic (pain reliever) & Antipyretic (fever)
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6
Q

Neuropathic pain

A 
injury to peripheral or central SENSORY nerves.
Hyperalgesia
Allodynia
Paresthesias
Dyesthesias
*DIFFERENT from nociceptive pain.
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7
Q

Nociceptive pain

A

caused by TISSUE DAMAGE releasing chemical pain mediators.

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8
Q

Hyperalgesia

A

increased pain evoked by noxious stimulus

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9
Q

Allodynia

A

pain caused by stimuli that are not normally painful. eg. touch, bed clothes, wind

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10
Q

Paresthesias

A

tingling, pins and needles, burning sensation

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11
Q

Dyesthesias

A

burning, shooting, electric shock-like sensation.

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12
Q

Fibromyalgia

A

chronic diffuse pain (18 tender point*)
CENTRAL SENSITIZATION
depression, fatigue, sleepy
Treated with anticonvulsant (pregabalin)

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13
Q

Gout

A

inflammatory join disease caused by incread uric acid in blood. Precipitates where temperature is lower (toes/ distal joints) Crystals attract leukocytes and increase inflammatory mediators. (joint damage)
Treated with NSAIDs and CORTICOSTEROIDS(prednisone) . Also with CHOLCHICINE. all decrease inflammation.

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14
Q

Migrane Headaches

A

Common & Classic Migraine: with Aura - fully reversibly sensory symptoms: visual, olfactory, difficulty of speech for 5-60 mins.
Treated with NSAIDS and TRIPTANS(Sumatriptan- seritonin agonist). NOT USED IN PREGNANCY AND CV DISEASE.
ERGOT derivatives - cause vasoconstriction (NO in CV) can cause retroperitoneal fibrosis (URETERAL Obstruction)

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15
Q

Migraine Prophylaxis

A

has to be more than 15days / month

Beta blockers, tricyclic antidepresents , Calcium channel blocker, Antieplieptics

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16
Q

Fomeprizole

A

treats Methanol toxicity. (poisoning)

17
Q

Ethylene glycol

A

anti freeze ; causes ACUTE RENAL FAILURE. Can be treated with Ethanol and Fomepizole.

18
Q

Major depression

A

TCAs, SSRIs, SNRIs, atypical Antidepressants

*Noradrenergic systems are inhibited.

19
Q

Two types of Depression

A

Major and Bipolar depression

20
Q

MAOIs (Monoamine Oxidase Inhibitors)

A

Tranylcypromine - irreversibly binds to MAO blocks MAOa & MAO B.
Moclobemide - reversibly binds to MAO-A. doesn’t alter MAO-B in the liver. (cheese and wine isn’t a problem)

21
Q

SNRIs (serotonin/norepinephrine reuptake inhibitors)

A

Includes: Atypicals & MAOIs. no affinity for any neurotransmitter receptors
Fewer adverse affects . DISCONTINUATION SYNDROME

22
Q

TCAs (Tricyclic antidepressants)

A

BLOCK serotonergic , a-adrenergic, histamine, and muscarinic receptors. NON SELECTIVE . Imipramine was first. 3 ring structure [*CLASSIFIED by structure]
*IPRAMINES & TRIPTYLINES

23
Q

NSRI (Non-selective reuptake inhibitors)

A

BLOCKS serotonin and Norepinephrine reuptake.

24
Q

Atypical Antidepressants

A

l

25
Q

Dysthymia

A

experience sadness

26
Q

Perinatal depression

A

depression surrounding childbirth.

27
Q

Parkinson’s disease

A

Treated with Dopamine stimulation and muscarinic receptor antagonists.

28
Q

Psychotic disorters (Schizophrenia)

A

Treated by blocking Dopamine systems and inhibition of Serotonin systems.

29
Q

Alzheimers

A

Treated by acetylcholinesterase inhibitors,

30
Q

SSRIs (Serotonin selective reuptake inhibitors)

A

more block of Serotonin.

Phpy 305 (5 decks)

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