just things to take note Flashcards
what is the component of phospholipid with the highest percentage in plasma membranes
phosphatidycholine
what is the importance of linolenic acid
reduce inflammation
what is the importance of linoleic acid`
precursoe for arachidonic acid
what are the fat soluble vitamins
A, D,E,K
example of lipid soluble anti oxidants which are not vitamins
alpha-tocopherol
beta-carotene
what is COX full name
cyclooxygenase
what are some cox inhibitors
aspirin
naproxen –> structurally similar so it is a competitive inhibitor which mimics critical fatty acid-dependent interactions at active site
what are the inhibitors for cholesterol synthesis
statin
what are the inhibitors for choesterol uptake
ezetimibe - blocks the sterol transporter preventing dietary cholesterol uptake
what are some hormone receptor inhibitors
tamoxifen ( estrogen)
flutamide (androgen)
why are carbohydrates not reliable as permananent storage sources
they are more soluble in water
what is heparin and its mechanism
heparin is an anti-coagulant
heparin binds to anti-thrombin 3–> activates it–> inhibits thrombin –> inhibit formation of clots
what is the formula for V0
v0 = vmax (concentration of substrate) / kmax + concentration of substrate
what is omeprazole
proton pump inhibitor
what is the action of omeprazole
blocks the K+ and hydrigen anti porter –> no secretion –> gastric acid is reduced
what is an anti-histimine receptor example and its action
chlorpheniramine
binds to the receptor binding site of histimine receptors reducing cell signalling
what is an example of antibodies as therapuetic blockage
dupilumab il4a monoclonal antibodies
what is the action of dupilumab il4a
block the convergent point for inflammatory responses –> no inflammatory response
what are some examples of peptidomimetics
sulfonamide
thioester
retroinverso
peptoid
the deal with tropocollagen and collagen
what happens to collagen if no vit c
collagen fibres are weakened as vit c is a cofactor
what is the intracellular ph range
6.8-7.4
