[JT U2] ABO Subgroups

Question 1

Subgroups are characterized by

Answer 1

lesser antigens

Question 2

This exists due to a defective enzyme that could not convert H-Ag to A or B-Ag

Answer 2

ABO subgroups

Question 3

ABO subgroups could not convert ___ to ___ or ___ Ag

Answer 3

H-Ag; A or B-Ag

Question 4

A subgroups are described by

Answer 4

Von Dungern

Question 5

A subgroups were described in what year

Answer 5

1911

Question 6

Most common subgroup

Answer 6

A subgroup

Question 7

80% of the A subgroup are

Answer 7

A1-Ag

Question 8

20% of the A subgroup are

Answer 8

A2-Ag

Question 9

Anti-A1 lectin is from _________________

Answer 9

Dolichos biflorus

Question 10

For transfusion, we prioritize the same _____________ between the donor and receiver

Answer 10

Blood type

Question 11

T/F:
A2 individuals produce anti-A1, therefore they are incompatible with A1

Answer 11

True

Question 12

If A2 is unavailable, what blood type is used for transfusion?

Answer 12

Type O

Question 13

A1 and A2 Subgroups are associated with what immunodominant sugar?

Answer 13

N-acetyl-d-galactosamine

Question 14

T/F:

A and B antigens have L-fucose

Answer 14

False

natabunan na yung L-fucose since converted na sila to A and B

Question 15

Naturally occurring IgM cold reacting antibody

Answer 15

A1 Antibody

Question 16

Antibody that usually reacts at temperatures only <37C

Answer 16

A1 Antibody

Question 17

A1 antibody is reactive at __C

Answer 17

37C

Question 18

Blood Group that has the greatest amount of H ag

Answer 18

O

Question 19

blood group that reacts with Anti-H since it has a lot of it unconverted

Answer 19

A2

Question 20

blood group most efficient in converting

Answer 20

A1B

Question 21

blood group that has the least amount of H ag

Answer 21

A1B

Question 22

What is the sequence of reactivity of Anti-H antisera with ABO blood groups from greatest amount of H-ag to least amount

Answer 22

O > A2 > B > A2B> A1 > A1B

Question 23

Lectins are known for their

Answer 23

specificity

Question 24

Source of Anti-H

Answer 24

Ulex europaeus

Question 25

Source of Anti-A

Answer 25

Helix pomatia

Question 26

Source of Anti-A1

Answer 26

Dolichos biflorus

Question 27

Source of Anti-B

Answer 27

Bandeiraea simplifocia (New genus: Griffonia)

Question 28

Bombay phenotype results from inheritance of a double dose of __ gene

Answer 28

h

Question 29

h gene is an

Answer 29

amorph

Question 30

most common type of bombay

Answer 30

Classical bombay (genotype) - non secretor

Question 31

T/F: In cases of emergencies, it is possible to transfuse Type O to a patient with Bombay blood

Answer 31

F

Question 32

A possible type of donation for patients with Bombay Blood who donate blood to themselves

Answer 32

Autologous donation

Question 33

What is used to differentiate Bombay phenotype from Type O

Answer 33

Anti-H (Ulex europaeus) - there is lack of L-fucose (H-ag in bombay)

Question 34

Phenotype where RBCs either completely lack H antigens or have small amounts of H antigens present

Answer 34

Para-Bombay Phenotypes

Question 35

Bombay phenotypes lacks the __ Ag

Answer 35

H

Question 36

T/F: Bombay phenotype has A, B, and H antigens

Answer 36

False

Question 37

Forward: Anti-A (-), Anti-B (-), Anti H (+) Reverse: A cell (+), B-cell (+), O cell (-) What Blood type is this?

Answer 37

O

Question 38

Forward: Anti-A (-), Anti-B (-), Anti H (-) Reverse: A cell (+), B-cell (+), O cell (+) What Blood type is this?

Answer 38

Bombay Blood

Question 39

Anti-A: (+) Anti A1: (+) What A subgroup phenotype?

Answer 39

A1

Question 40

Anti-A: (+) Anti A1: (-) What A subgroup phenotype?

Answer 40

A2