Journals Flashcards
What were the primary findings of a study by Sutalo et al on the effect of orally administered ranitidine and once daily or twice daily orally administered omeprazole on intragastric pH in cats?
JVIM 2015 29.
- Only twice daily PO administered omeprazole significantly suppressed gastric acidity in healthy cats
- Once daily omeprazole and standard doses of ranitidine (1.5-2.3mg/kg) were not effective acid suppressants in cats, with the pH not differing from the placebo group
What were the primary findings of a study by Tolbert et al on the efficacy of IV administration of combined acid suppressants in healthy dogs?
JVIM 2015 29
- There was no significant difference in the mean percentage of time the intragastric pH was >/= 3 or 4 between groups of patients treated either with pantoprazole alone or a combination of pantoprazole and famotidine
- Pantoprazole alone (at 1mg/kg IV q12h) achieved pH goals that have been established for human patients with acid-related disorders
- Short-term combination treatment with famotidine/pantoprazole is not superior to pantoprazole alone for increasing intragastric pH in dogs
What were the primary findings of a study by Parente et al regarding serum concentrations of gastrin after famotidine and omeprazole administration to dogs?
JVIM 2014 28
- Omeprazole was shown to cause a significant increase in serum gastrin concentrations; famotidine induced a transient increase in serum gastrin that peaked at administration day 3 and declined thereafter
- By day 7 after cessation of both drugs, the gastrin levels were the same as those obtained pre-treatment
- A 7 day withdrawal from short-term administration (7 days) of famotidine or omeprazole is sufficient for serum gastrin to return to baseline concentrations
What were the primary findings of a study by Paek et al regarding serum adipokine concentrations in dogs with acute pancreatitis?
JVIM 2014 28
- SErum concentrations of leptin, resistin, visfatin, IL6, 8 and 10 were significantly higher in dogs with acute pancreatitis, whereas adiopnectin concentration was significantly lower
- Dysregulation of adipokines may be involved in the pathogenesis of AP
- Significant differences in the serum concentrations of leptin and adiponectin in survivors and nonsurvivors
What were the primary findings of a study by Parkinson et al evaluating the effect of orally administered acid suppressants on intragastric pH in cats?
JVIM 2015 29
- Omeprazole (either a fractionated tablet or a reformulated paste) was superior to famotidine in regards to acid suppression
- The fractionated tablet of omeprazole appeared to be an effective acid suppressant despite disruption of the enteric coating
What were the primary findings of a study by Unterer et al regarding endoscopically visualized lesions, histologic findings, and bacterial invasion in dogs with AHDS?
JVIM 2014 28.
- Acute mucosal lesions were only found in the intestines, not in the stomac
- Clostridium (C.perf) detected in small intestinal mucosa by culture or immunohistopathology in all dogs with signs of HGE, but only in one control dog
- Apparent association?
What were the primary findings of a study by Kempf et al examining high resolution manometric evaluation of the effects of cisapride and metoclopramide adminstered orally on lower esophageal sphincter pressure in awake dogs?
AJVR 2014 75
- Orally administered cisapride may be of benefit in canine patients for whicn an increase in LES pressure is desired
- Orally adminstered metoclopramide did not affect LES resting pressures in dogs
- The LES pressures differed significantly only between the placebo and cisapride treatment groups
What were the primary findings of a study by Davies et al examining the incidence of and risk factors for postoperative regurgitation and vomiting in dogs (244 cases)?
JAVMA 2015 246
- 12% of dogs developed post-operative regurgitation/vomiting
- Risk factors included GI surgery, premedication without strong sedatives, ASA score of 4, history of vomiting or regurg, emergency surgery, neuro surgery, sevo anesthesia and being sexually intact.
What were the primary findings of a study by Pratt et al examining sewing needle foreign body ingestion in dogs and cats?
JAVMA 2014 245
- Esophageal and gastric regions most common location for a sweing needle
- GI perfo identified in 17% of animals
- Sewing needles in the esophagus and stomach were successfully removed endoscopically in 8/9 dogs and 18/19 cats
- Endoscopy is highly successfully and should be recommended to prevent GI tract perforation and associated morbidity
What were the findings of a study by Zollers on capromorelin in dogs with reduced appetite?
JVIM 2016
- Improved appetite compared to placebo
- Seems to be an effective treatment for stimulation of appetite in dogs; is the first ghrelin receptor agonist effective for this indication
What were the findings of a study by Chartier et al on pancreas-specific lipase concentrations and amylase and lipase activities in peritoneal fluid of dogs with suspected pancreatitis?
Vet Journ 2016
- Peritoneal fluid cPLI concentration was highly sensitive as a complementary diagnostic tool in dogs with suspected AP
- Peritoneal fluid lipase activity was not as sensitive as cPLI concentrations
What were the findings of a study by Sutton et al on perioperative morbidity and outcome of esophageal surgery in dogs and cats?
JAVMA 2016
- Pneumomediastinum and leukopenia were negative prognostic factors for dogs being discharged from the hospital
- Most common postop coplications were regurgitation and esophageal stricture formation
- 90% of patients discharged from hospital
- Dogs treated for more extensive lesions as well as those undergoing esophagectomy or R&A were more likely to develop post-op complications
What were the findings of a study by Manning et al regarding intermittent at home suctioning of esophageal content for prevention of recurrent aspiration pneumonia in dogs with megaesophagus?
JVIM 2016
- Using e-tube in 3 dogs, PO in 1 dog
- After initiation of suctioning, dogs survived for ~13.5 months; 2 dogs had no additional episodes of pneumonia
What were the findings of a study by Gould et al on the effect of omeprazole on serum calcium, magnesium, cobalamin, gastrin concentration and bone in cats?
JVIM 2016
- Prolonged PPI treatment may result in hypergastrinemia
- Abrupt PPI withdrawal may result in rebound acid hypersecretion in cats
What were the findings of a study by Yuki et al on the clinical utility of diagnostic laboratory tests in dogs with acute pancreatitis?
JVIM 2016
- Lipase may be useful for diagnosing AP
- High AlT activity may be associated with prolonged duration of hospitalization
- CRP may be useful as a biomarker for monitoring of recovery from AP
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