Jones 1 (Periodontal Pathology) Flashcards
- Linear band of erythema involving the free gingival margin
- Punctate or diffuse erythema of the alveolar mucosa
- May represent an unusual pattern of candidiasis
LINEAR GINGIVAL ERYTHEMA
- Ulceration and necrosis of one or more interdental papillae
- No loss of periodontal attachment
- Gingival necrosis, bleeding, pain and halitosis
NECROTIZING ULCERATIVE GINGIVITIS (NUG)
- Gingival ulceration and necrosis associated with rapidly progressing loss of periodontal attachment
- Multiple isolated defects
- Edema, severe pain, spontaneous hemorrhage
- No deep pocketing
- Does not respond to conventional periodontal therapy
NECROTIZING ULCERATIVE PERIODONTITIS (NUP)
- Massive areas of tissue destruction
- May involve soft tissue or bone
- Results in sequestration
NECROTIZING STOMATITIS
- “Epulis”: a generic term for any tumor of the gingiva or alveolar mucosa
- Associated with the flange of an ill-fitting denture
- Hyperplastic fibrous connective tissue in the alveolar vestibule
- Usually develops on the facial alveolar ridge
- Maxilla or mandible; F > M
EPULIS FISSURATUM
- Reactive tissue growth that usually develops underneath a denture
- Related to:
- Ill-fitting denture
- Poor denture hygiene
- Wearing the denture 24 hours a day
- May also occur in dentate patients who are mouth breathers or have a high arched palate
- Usually occurs on the hard palate
- Erythematous mucosa with a pebbly or papillary surface
INFLAMMATORY PAPILLARY HYPERPLASIA
- Represents an exuberant tissue response to local irritation or trauma
- Smooth or lobulated mass that bleeds easily
- 75%-85% of cases occur on the gingiva
- MXG > MDG; anterior > posterior
- Facial > lingual
- Children and young adults; F > M
PYOGENIC GRANULOMA
- Represents a reactive lesion caused by local trauma or irritation
- Represents the soft tissue counterpart of the central giant cell granuloma
- Only occurs on the gingiva or edentulous alveolar ridge
- MDG > MXG
- Any age; 52%-60% occur in females
- Radiographic findings
- “Cupping” resorption of the underlying alveolar bone may occur
PERIPHERAL GIANT CELL GRANULOMA
- Some are thought to begin as a pyogenic granuloma that has undergone fibrous maturation and subsequent calcification
- Does not represent the soft tissue counterpart of a central ossifying fibroma
- Occurs exclusively on the gingiva
- MXG > MDG
- Teens and young adults (10-19)
- 2/3 occur in females
PERIPHERAL OSSIFYING FIBROMA
- Histogenesis is uncertain
- Occurs exclusively on the alveolar ridge of a newborn
- Multiple tumors develop in 10% of cases
- Maxillary ridge > mandibular ridge
- 90% occur in females
CONGENITAL EPULIS
- Autosomal recessive trait
- Mutation and loss of function of the cathepsin C gene on the long arm of chromosome 11
- Patients demonstrate oral and dermatologic manifestations
PAPILLON-LEFEVRE SYNDROME
- Treatment
- Debridement combined with povidone-iodine irrigation
- Antimicrobial therapy: metronidazole, chlorhexidine, antifungals
- Follow-up care
- Long-term maintenance
NECROTIZING ULCERATIVE GINGIVITIS (NUG) and NECROTIZING ULCERATIVE PERIODONTITIS (NUP) Treatment
- Treatment
- Antibiotics
- Debridement of necrotic tissue
NECROTIZING STOMATITIS Treatment
- Histopathologic features
- Hyperplastic fibrous connective tissue
- Surface epithelium often demonstrates pseudoepitheliomatous hyperplasia
EPULIS FISSURATUM Histopathologic features
- Treatment and prognosis
- Surgical excision
- Ill-fitting denture should be remade or relined
EPULIS FISSURATUM Treatment and prognosis
- Histopathologic features
- Mucosa exhibits numerous papillary growths
- May demonstrate pseudoepitheliomatous hyperplasia
- May be associated with Candida
INFLAMMATORY PAPILLARY HYPERPLASIA Histopathologic features
- Treatment and prognosis
- Early lesions
• Remove the denture
• Topical or systemic antifungal therapy - Advanced lesions
• Excision of the hyperplastic tissue
• Reline or remake the dentures
- Early lesions
INFLAMMATORY PAPILLARY HYPERPLASIA Treatment and prognosis
- Histopathologic features
- Highly vascularized granulation tissue
- Often associated with surface ulceration
PYOGENIC GRANULOMA Histopathologic features
- Treatment and prognosis
- Conservative surgical excision
- Gingival lesions often recur if adjacent teeth are not thoroughly scaled to remove irritation
- 3%-15% recurrence rate
PYOGENIC GRANULOMA Treatment and prognosis
- May arise in pregnant women: pregnancy gingivitis
- 1st trimester to the 7th month
- Related to an increase in estrogen and progesterone levels as pregnancy progresses
PYOGENIC GRANULOMA Variation
- Histopathologic features
- Proliferation of multinucleated giant cells set in a vascularized fibrous connective tissue stroma
- Hemorrhage and hemosiderin
- Surface ulceration in 50% of cases
PERIPHERAL GIANT CELL GRANULOMA Histopathologic features
- Treatment and prognosis
- Local surgical excision
- Scale adjacent teeth
- 10%-18% of lesions recur
- May be associated with primary hyperparathyroidism
PERIPHERAL GIANT CELL GRANULOMA Treatment and prognosis
- Histopathologic features
1. Fibrous proliferation with the formation of a mineralized product: cementum, bone, or dystrophic calcification
PERIPHERAL OSSIFYING FIBROMA Histopathologic features
- Treatment and prognosis
- Local surgical excision
- Scale adjacent teeth
- 8%-16% recurrence rate
PERIPHERAL OSSIFYING FIBROMA Treatment and prognosis
- Histopathologic features
- Large, rounded cells with abundant granular, eosinophilic cytoplasm
- No pseudoepitheliomatous hyperplasia
- Cells do not stain with s-100 protein
CONGENITAL EPULIS Histopathologic features
- Treatment and prognosis
- Surgical excision
- No recurrence
- Complete regression without treatment has been reported
CONGENITAL EPULIS Treatment and prognosis
- Dermatologic manifestations
- First become evident by age 3
- Diffuse keratosis on the palms, soles, dorsa of hands and feet, elbows, knees
- White, yellow, or brown plaques that develop crusts, cracks, and fissures
PAPILLON-LEFEVRE SYNDROME Dermatologic manifestations
- Oral manifestations
- Advanced periodontitis of the primary and secondary dentitions
- Hyperplastic and hemorrhagic gingivitis
- Loss of bone support leading to teeth floating in space
- Exfoliation of all primary teeth by age 4 or 5
- Once edentulous the gingiva returns to normal until the permanent teeth erupt and the cycle starts over
- Exfoliation of all permanent teeth by age 15
- Periodontal destruction linked to infection with Aggregatibacter actinomycetemcomitans
PAPILLON-LEFEVRE SYNDROME Oral manifestations
- Treatment
- Skin: retinoids
- Oral
• Difficult: disease often progresses until all teeth are lost
• Antibiotic regimen: amoxicillin and metronidazole
• Rigorous oral hygiene, prophylaxis, chlorhexidine mouth rinses
PAPILLON-LEFEVRE SYNDROME Treatment