Joints, Synovial Fluid and Cartilage Flashcards

1
Q

What are the 3 broad types of joint?

A

Fibrous - densely packed collagen - very strong and under tension

Cartilaginous - layer of hyaline cartilage found in between bones rather than densely packed fibrous collagen

Synovial - cavity, synovial fluid, all work to provide as low a friction environment as possible for best articulation and movement

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2
Q

What are 3 places where you might find a fibrous joint?

A

Cranial Sutures

Periodontal ligaments

Interosseous membranes - between forearm and lower leg bones, very tough and strong. Although important to note that they don’t prevent pronation etc due to the orientation of the densely packed collagen fibres

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3
Q

What are the 2 types of cartilaginous joint?

A

Primary cartilaginous (synchrondoses) - only hyaline cartilage joins the two bones; typically found in the epiphyseal growth plates of developing long bones.

Secondary cartilaginous (symphyses) - hyaline AND fibrocartilage found; e.g. an IV disc where there is a fibrocartilage disc and hyaline cartilage covering the bone.

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4
Q

What are some common features in almost all synovial joints?

A
Synovial cavity
Articular cartilage
2 types of membrane:
Synovial membrane on the inside (secretes synovial fluid)
Fibrous capsule on the outside
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5
Q

What are some features found in some, but not all, synovial joints?

A

Articular discs
Ligaments
Bursae (fluid filled cushioning sacs that prevent friction in joints)

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6
Q

What are 6 different types of synovial joint?

A
Plane
Condylar
Hinge
Saddle
Pivot
Ball and Socket
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7
Q

What 3 key factors are important in joint stability?

A

Shape of the articulating surfaces
Capsule and ligaments of the joints (strength)
Stabilising musculature - especially with things like rotator cuffs in the shoulder

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8
Q

What kind of cartilage are menisci made up of?

A

Fibrocartilage

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9
Q

What are a few features that can help differentiate hyaline and fibrocartilage?

A

Fibrocartilage has densely packed collagen fibres making it very mechanically strong; hyaline still has collagen but is much less densely packed

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10
Q

What differences can be seen through the different layers of hyaline (articular) cartilage?

A

Superficial/Tangential layer - chondrocytes are flatter and produce collagen and glycoproteins like lubricin

Transitional layer - chondrocytes are rounder and produce more proteoglycans like aggrecan (binds water really well)

Collagen fibres change orientation from superficial to deep (horizontal to vertical). Orientation tells you about the main direction of forces on the cartilage.

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11
Q

What percentage of hyaline cartilage is water and what is its significance?

A

> 75% (thanks to the binding properties of aggrecan)

It is incompressible so the cartilage is really strong under compression

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12
Q

What are the 3 key attributes of cartilage in general? (3 A’s)

A

Avascular
Aneural
Alymphatic

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13
Q

How does cartilage maintain a supply of nutrients and get rid of waste?

A

Via synovial fluid produced by the synovial membrane/synovium

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14
Q

Describe the synovium

A

Made up of tendon-like sheets
Synoviocytes present constantly producing synovial fluid
Rich capillary network to supply nutrients
No epithelial lining so we get a direct exchange of nutrients and waste between blood and synovial fluid.

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15
Q

What are the 2 types of synoviocyte?

A

Type A - look like mAcrophages, remove debris and contribute to synovial fluid production

Type B - look like fiBroblasts and are the main producers of synovial fluid

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16
Q

What makes up synovial fluid?

A

Hyaluronic acid and lubricin; fluid from plasma and a whole host other stuff

17
Q

What is the rate of turnover for synovial fluid?

A

~2 hours

18
Q

What are some functions of synovial fluid?

A

Lubrication

Removal of Waste

Nutrition of cartilage

19
Q

What are the 3 different types of lubrication in synovial joints?

A

Boundary - glycoproteins like lubricin bind to receptors on the surface of articular cartilage and form a thin film

Hydrodynamic - like aquaplaning as surfaces are kept apart by a fluid boundary which changes viscosity with velocity and load

Weeping - fluid is squeezed out of the cartilage into the synovial cavity.

20
Q

What are bursae?

A

Fluid filled synovial sacs found in some joints that help to provide cushioning and reduce friction.
They have the potential to be infected and inflamed (bursitis)

21
Q

What changes happen in joints with ageing?

A

Viscosity of synovial fluid decreases - slower movement and reduced lubrication

Water content of cartilage drops so reduced shock absorption