Jim Reid Flashcards
what is the formula to find t in a unimolecular irreversible reaction with the [A] at the start and a given time
eg. time till 95% completion
ln([A]t / [A]0) / -k
eg. ln(0.05) / -k
what order are unimolecular reactions always
first, there is only on concentration term
how do you work out the ratio of [A]eq : [B]eq in unimolecular reversible reactions
1 : k
at eq. forwards and reverse k is the same
what is the formula to work out [B] at a given time in an unimolecular irreversible reaction
[B] = [A]0(1-e^-kt)
headings of the table of the numerical approach unimolecular irreversible
t, [A], rate of change of [A] in uMs-1, d[A] in whatever time interval you want
what is the formula for [A] at a given time in an unimolecular irreversible reaction
[A] = [A]0e^-kt
in a unimolecular reversible reaction what is the average time A
aka lifetime
A = 1/k1
in a unimolecular reversible reaction what is the average time B
B = 1/k-1
what is the proportions of [A] and [B] at equilibrium
[A] = 1/1+K, [B] = K/1+K
what does kobs =
k+1 + k-1
observed rate
how to work out [B] from [A]0 and [A]T in unimolecular reversible
[B] = [A]0 - [A]T
what is kobs in unimolecular reversible (theory)
This is the only term with time dependence it will be a term between 1 and 0 determining how much of the reaction has taken place
for a question such as How long will it take for the reaction to reach 95% completion? for a unimolecular reversible reaction what equation would you use
t = ln(x)/-kobs
derived from x = e^-kobs
in this case x = 0.05 because that’s the amount of reaction which would be remaining aka [A]t/[A]0
equation for the time depenance of bimolecular irreversible at equilibrium
d[A]/dt = -k+1[A][B] + k-1[C] = 0
fraction of protein bound to ligand equation
[PL]/[P]T = [L]/[L]+Kd
what does [A]t = in bimolecular irreversible
[A]0 x e^kobst
where kobs = k[B]
when [B]»[A]
rate of change
Δ[A] / Δt = -k[A]
definition of rate
change in concentration over time
Rate constant
coefficient of proportionality relating the rate of a chemical reaction at a given temperature to the concentration of reactant (in a unimolecular reaction) or to the product of the concentrations of reactants.
what is 1/k1 (explanation in words)
average lifetime in state A
what is the general rule for the left side of the rate of change equation
sum of the rate terms eg.
-k[A] in irreversible
-k1[A] + k-2[B] in reversible
-k[A][B] in bimol. irreversible
-k1[A][B] + k-1[C] bimol. reversible
what is the average time in B in a reversible reaction
1/k-1 (backwards rate)
what is a sense check for ratio/proportion calculations(reversible)
B should be higher because forward rate should be higher (check the question for this)
The numbers should add up the the original concentration
what needs to assumed (or done to experimental conditions) to use in analytical approach in bimolecular irreversible
that [A]»[B] so it is pseudo first order
so we can treat [B] as if it doesn’t change in the reaction
