jaundice

Question 1

what is the cut off range for bilirubin level in jaundice?

Answer 1

> 2.5mg/dL

Question 2

what is the classic manifestation of jaundice ?

Answer 2

Sclera icterus

Question 3

Problems in Bilirubin metabolism leads to what disease?

Answer 3

hepatic jaundice.

Question 4

What is the enzyme responsible for conversion of UCB to CB?

Answer 4

Uridine gulcuronyl transferase

Question 5

what is the byproduct of RBC metabolism that converts to Unconjugated Bilirubin?

Answer 5

protoporphyrin

Question 6

Clinical Manifestation : Dark Urine, High serum UCB, Pigmented Bilirubin gall stones. No findings of UCB in urine. What is the dx?

Answer 6

extravascular hemolysis / ineffective erythropoiesis

Question 7

what is the most important clinical finding in a new born baby with increased serum UCB, with neurological defects and high serum UCB?

Answer 7

Kernicterus.

Question 8

what is the enzyme that is missing In an baby with kernicterus?

Answer 8

Uridine Glucuronyl Transferase.

Question 9

Jaundice with stress, lab findings show relatively low amounts of Uridine Glucuronyl Transferase. What is this dx?

Answer 9

Gilbert Syndrome

Question 10

Liver findings show dark coloured liver with No presence of UGT levels. accompanied with jaundice. what is dx?

Answer 10

Crigler-Najjar syndrome

Question 11

what is physiological manifestation of Dubin Johnson syndrome accompanied with lab findings of increased CB levels?

Answer 11

dark liver.

Question 12

What structure is missing in a person with increased CB and has a dark liver with Jaundice?

Answer 12

Bilirubin Canalculi transport protein.

Question 13

Xanthomas, pruritus, hypercholestrolemia with xanthomas, and steatorrhea associated with cholangiocarcinoma is a classic case of what disease?

Answer 13

biliary obstruction

Question 14

what are the laboratory findings in obstructive jaundice?

Answer 14

increased CB and ALP
deceasedurine urobilinogen