Izard Drugs for DVT & PE Flashcards
1
Q
What are the prostanoids used for Pulmonary Htn?
A
- Epoprostenol
- Treprostinin
- Iloprost
- Selexipag
2
Q
What are the Endothlein antagonists used for puplmonary htn?
A
- Bosentan
- Ambrisentan
- Macicentan
3
Q
What are the PDE 5 inhibitors used for pulmonary htn?
A
- Sildenafil
- Tadalafil
4
Q
What are the guanylate cyclase sensitizers used for pulmonary htn?
A
riociguat
5
Q
What do you use if you have a positive vasopressor test in a patient with PAH?
A
CCB
6
Q
What treatments are routinely sued with little impact on PAH progression?
A
- Anticoagulants
- Diuretics
- Oxygen therapy
7
Q
Epoprostenol effects and MOA?
A
- Mimics prostacyclin compound
- lowers pulmonary arterial resistance and decreases pulmonary artery pressure
8
Q
Epoprostenol toxicities?
A
- Sepsis due to chronic catheter
- Life threat if pump lines clogged
- N/V
- HA
- Jaw pain
- Flushing
9
Q
Treprostinil MOA and effects?
A
- Mimics prostacyclin
- Lowers pulm art pressure & resistance
10
Q
Pharmacokinetcs of treprostinil?
A
- SubQ infusion
- longer half life doesn’t require refrigeration
- qid inhalation is available
11
Q
AE of Treprostinil?
A
- Sepsis due to chronic catheter
- site pain
- jaw pain
- diarrhea
- edema
- nausea
- If inhaled:
- Cough
- HA
- Throat irritation
12
Q
Iloprost pharmacokinetics?
A
Inhale 6-9x daily
13
Q
Iloprost AE?
A
- fainting due to hypotension
- cough
- HA
- flushing
- jaw pain
14
Q
Selexipag pharmacokinetics and AE?
A
- BID po, Expensive
- HA
- Flushing
- Diarrhea N/V
- Jaw limb and muscle pain
- skin rash
15
Q
Bosentan MOA and effects?
A
- Nonspecifically blocks ETa and ETB endothelin receptors
- improves exercise tolerance and slows progression
