iv hypnotics Flashcards
1
Q
briefly tell about midazolam
A
-Midazolam is a benzodiazepine.
-Benzodiazepines bind at a site lying between the α and γ subunits of the GABA A receptor.
- This causes the receptor to become more permeable to chloride ions, which causes hyperpolarization of the neurone.
-This leads to the observed effects of sedation, hypnosis, anxiolysis and anti-epileptic action.
-Barbiturates bind solely at the α subunit.
-Midazolam has a shorter half-life than lorazepam
-metabolized by the cytochrome P450 enzyme family to
an active metabolite: hydroxyl-midazolam glucronide.
- This metabolite is renally excreted and is partially removed by renal replacement therapy.
-Midazolam is hardly cleared by renal replacement therapy at all.
-Co-administration of some antimicrobials, such as fluconazole or macrolides, inhibit the cytochrome P450 system, leading to increased effects of midazolam.
