anti depressant

Question 1

list drugs that inhibit MAO enzyme

Answer 1

• Hydralazine
• Isoniazid
• Linezolid
• Methylene blue

Question 2

tell about Monoamine Oxidase Inhibitors

Answer 2

-The MAOI group of drugs is administered orally for the treatment of resistant depression, obsessive compulsive disorders, chronic pain syndromes and migraine.

-MAO is present as a variety of isoenzymes within presynaptic neurones and is respon- sible for the deamination of amine neurotransmitters.

-They have been classified as types A and B.

-Following their inhibition there is an increase in the level of amine neurotrans- mitters, which is thought to be the basis of their central activity.

-MAO-A preferentially deaminates 5-HT and catecholamines, while MAO-B preferentially deaminates tyramine and phenylethylamine.

-There are now two generations of MAOIs.

-The original generation inhibit MAO irreversibly and non-selectively (i.e. MAO-A and -B) while the new generation selectively and reversibly inhibit only MAO-A (RIMA).

-Neither group is used as first-line therapy because of the potential for serious side effects and hepatic toxicity.