IV Anesthetics

Question 1

Propofol brand name and mechanism of action

Answer 1

Diprivan

Thought to act through positive modulation of the inhibitory function of GABA through GABA-A receptors

Question 2

Diprivan benefits: (3)

Answer 2

1. decreased ICP
2. rapid emergence
3. anti-nauseant properties

Question 3

Diprivan disadvantages: (4)

Answer 3

1. resp/cvs depressant
2. PRIS (persistent bradycardia leading to asystole)
3. pain at the site of admin
4. no analgesic properties

Question 4

Diprivan onset and duration of action:

Answer 4

Onset: 15-30 seconds
Duration: 5-10 minutes

Question 5

Rhabdomyolysis definition:

Answer 5

Destruction of striated muscle cells

Question 6

Diprivan drug class (4)

Answer 6

IV anesthetic, sedative, hypnotic, induction agent

Question 7

Diprivan induction dose:

Answer 7

1-2.5 mg/kg

Question 8

Diprivan considerations: (2)

Answer 8

vivid dreams

allergy sensitive - egg

Question 9

Ketamine brand name

Answer 9

Ketamar

Question 10

Ketamine drug class (4)

Answer 10

Dissociative IV anesthetic, sedative, hypnotic, induction agent

Question 11

Ketamine mechanism of action/anesthesia effects (4)

Answer 11

Dissociative anesthesia&raquo_space; analgesia, reduced sensory perception, immobility, amnesia

Question 12

Ketamine mechanism of action/hypnotic effects

Answer 12

Hypnotic effects mediated by blockade of NMDA receptors

Question 13

Ketamine advantages: (3)

Answer 13

1. minimal respiratory depression
2. increases blood pressure
3. bronchodilation

Question 14

Ketamine disadvantage:

Answer 14

Increased chance of vivid dreams/hallucinations on emergence, can cause delirium

Question 15

Ketamine onset and duration of action:

Answer 15

Onset: 30 seconds
Duration: 30 minutes

Question 16

Ketamine doses: (2)

Answer 16

0.5-2 mg/kg or 3-5 mg/kg IV

Question 17

Ketamine considerations: (2)

Answer 17

Provides general anesthesia while preserving laryngeal and pharyngeal reflexes
Enhances succinylcholine