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PT Neuro NATE EDITION > IV Anesthetics > Flashcards

IV Anesthetics Flashcards

1
Q

propofol mechanism

A

potentiates GABAa receptor

more Cl- conduction; open longer

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2
Q

ketamine mechanism

A

NMDA receptor antagonist

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3
Q

etomidate mechanism

A

potentiate GABAa receptor

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4
Q

dexmedetomidine mechanism

A

a2R agonist

inhbits release of NE @ presynaptic terminal in CNS

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5
Q

benzodiazepines’ mechanism

A

potentiate GABAa receptor

increase Cl- conductance frequency

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6
Q

barbiturates’ mechanism

A

potentiate GABAa receptor

increase Cl- conductance duration

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7
Q

adverse effects of propofol

A

pain on injection

cardio and respiratory depression

egg allergy

propofol infusion syndrome(rare)

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8
Q

adverse effects of ketamine

A

increased BP, HR, CO

increased mouth/throat secretions

lowers seizure threshold

emergence reaction(nightmares, hallucinations, visual distortion)

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9
Q

adverse effects of etomidate

A

adrenocortical suppression

pain on injection

myoclonic movements

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10
Q

adverse effects of dexmedetomidine

A

CV depression(bradycardia, hypotension)

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11
Q

adverse effects of benzodiazepines

A

decreased BP

pain on injection

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12
Q

adverse effects of barbiturates

A

decreased BP

respiratory depression

exacerbates AIP(acute intermittent porphyria)

pain if infiltrates paravenous tissue

precipitates when mixed w/acidic drugs

methohexital activates epileptic foci

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13
Q

uses of propofol

A

induction on anesthesia

maintenance of anesthesia

sedation via repeated bolus (endoscopy, MRI, dental extraction)

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14
Q

clinical uses of ketamine

A

induction of anesthesia

maintenance of anesthesia

sedation(short, painful procedures: dressing chanegs, suturing)

post-op pain(major abdominal, thoracic, orthopedic)

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15
Q

clinical uses for etomidate

A

induction of anesthesia in CV unstable pts

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16
Q

clinical uses for benzodiazepines

A

anti-anxiety pre-op

sedation for short term procedures(midazolam)

17
Q

clinical uses for barbiturates

A

induction of anesthesia(thiopental)

neuroprotection(decrease CBF, ICP, CMRO2)

treatment of anxiety, seizures, insomnia

18
Q

advantages of ketamine

A

analgesic

minimal resp. depr.

can be given IV, IM, PO, rectal

19
Q

advantages of propofol

A

amnesia

rapid onset/offset

antiemetic

neuroprotective

20
Q

advantages of etomidate

A

CV stability

minimal respiratory depression

21
Q

advantages of dexmedetomidine

A

sedation and analgesia with minimal respiratory depression

PT Neuro NATE EDITION (4 decks)

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