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Drugs For PUD > Item Question > Flashcards

Item Question Flashcards

1
Q

What is PUD

A
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2
Q

Sites

A
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3
Q

Kothay besi hoy?

A

1st part of duodenum

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4
Q

Causative organism

A

H.pylori

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5
Q

Virulence kivabe kore?

A
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6
Q

(H.Pylori)Test kivabe korba?

A

Urea breath test

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7
Q

Enzyme produced by H pylori

A

Urease

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8
Q

What are the defensive mechanism of gastroduodenal mucosa

A
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9
Q

What are the damaging force

A
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10
Q

Classify drugs for peptic ulcer disease

A
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11
Q

What are the systemic antacids

A
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12
Q

What are the non systemic antacid

A
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13
Q

Which is better?systemic or non systemic?

A

Non systemic

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14
Q

why non-Systemic is better?

A

Not absorbed
No acid base abnormalities

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15
Q

Criteria of ideal antacid

A
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16
Q

Criteria

A
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17
Q

Bazar a j antacid pawa jay Tate ki thake?

A

Mg(OH)2 and Al(OH)3

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18
Q

Benefit of combination of magnesium hydroxide and aluminium hydroxide

A

MOD-magnesium hydroxide causes osmotic diarrhea
aluminium hydroxide causes constipation
So in combination they minimise GIT adverse effect

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19
Q

What are the ppi’s?

A
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20
Q

mechanism of Action proton pump inhibitor

A
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21
Q

Adverse Effects of omeprazole?

A
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22
Q

Why ppi cause subnormal vit B12 level?

A

Decreased ifc

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23
Q

Why infection increases in ppi?.

A

HCl secretion less,less first line defence

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24
Q

Why ranitidine was banned?

A

Carcinogenesis
presence of low levels of an impurity called N-nitrosodimethylamine (NDMA). NDMA is classified as a probable human carcinogen (a substance that could cause cancer) based on animal studies.

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25
Q

Adverse effect of ranitidine?

A
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26
Q

Why cimetidine banned?

A
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27
Q

Is cimetidine a drug inducer or drug inhibitor?

A

Inhibitor
Increase warfarin toxicity

28
Q

What happens if you give ranitidine injection rapidly?

A

Bradycardia
Hypotension
So we will never give rapidly

29
Q

What is prostaglandin analogue?

A

Misoprostol

30
Q

NSAID induced peptic ulcer mechanism

A

NSAID is acidic
So it is unionised in acidic media(stomach)
It is absorbed to parietal cell.
Irritation bleeding perforation korbe

31
Q

Which is best drug for NSAID induced PUD

A

Misoprostol

32
Q

Why misoprostol used in NSAID induced PUD

A

Prostaglandin improves mucosal blood flow
Inhibits the HCl
Regenerative capacity increase
Secretion barabe

33
Q

What are the cytoprotective agents?

A
34
Q

Mechanism of sucralfate?

A
35
Q

Adverse effects of bismuth

A
36
Q

Triple therapy with dose?

A
37
Q

PPI continue korba kotodin?(in triple therapy)

A

4-6 wk

38
Q

Name laxatives with classification

A
39
Q

A patient has came with constipation which drug is given?

A

Firstly non pharmacologic approach
Then laxative

40
Q

Mechanism of ispaghula husk

A
41
Q

Adverse effects of ispaghula husk

A
42
Q

Contraindications of ispaghula husk

A
43
Q

Mechanism of lactulose?

A
44
Q

Adverse effect of lactulose?

A
45
Q

Indication of lactulose?

A
46
Q

Contraindications of lactulose?

A
47
Q

Enema kkhn use korbo?

A
48
Q

What are the anti emetics?

A
49
Q

A patient with hyperemesis in 1st trimester,what will you give?

A

Cyclizine,meclizine

50
Q

What will you give in nausea vomiting motion sickness?

A

Scopolamine
Cyclizine
Meclizine
Promethazine

51
Q

Cancer chemotherapy patient hole ki DBA?

A

Ondansetron oi group

52
Q

Indication of metoclopramide?

A
53
Q

Why metoclopramide given in post partum lactation instead of domperidone?

A

BBB and placenta cross

54
Q

Which antiemetic cause extra pyramidal syndrom?

A
55
Q

Metoclopramide mechanism

A
56
Q

Ondansetron,granisetron indication

A
57
Q

Mechanism of ondansetron

A
58
Q

Where is chemoreceptor trigger zone?inside BBB or outside?

A
59
Q

BBB cross kore na amn drug a emesis hoy?

A

Ha hote pare..Karon chemoreceptor trigger zone BBB er baire thake

60
Q

Name drugs for IBS?

A
61
Q

What is the role of TCA in IBS ?

A
62
Q

What are the drugs for IBD ?

A
63
Q

What are the drugs given in diarrhea?

A
64
Q

Why loperamide is used instead other opioid?

A
65
Q

Composition of ors ?

A
66
Q

Role of glucose in ORS?

A

Drugs For PUD (2 decks)

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