Item Question Flashcards
What is PUD
Sites
Kothay besi hoy?
1st part of duodenum
Causative organism
H.pylori
Virulence kivabe kore?
(H.Pylori)Test kivabe korba?
Urea breath test
Enzyme produced by H pylori
Urease
What are the defensive mechanism of gastroduodenal mucosa
What are the damaging force
Classify drugs for peptic ulcer disease
What are the systemic antacids
What are the non systemic antacid
Which is better?systemic or non systemic?
Non systemic
why non-Systemic is better?
Not absorbed
No acid base abnormalities
Criteria of ideal antacid
Criteria
Bazar a j antacid pawa jay Tate ki thake?
Mg(OH)2 and Al(OH)3
Benefit of combination of magnesium hydroxide and aluminium hydroxide
MOD-magnesium hydroxide causes osmotic diarrhea
aluminium hydroxide causes constipation
So in combination they minimise GIT adverse effect
What are the ppi’s?
mechanism of Action proton pump inhibitor
Adverse Effects of omeprazole?
Why ppi cause subnormal vit B12 level?
Decreased ifc
Why infection increases in ppi?.
HCl secretion less,less first line defence
Why ranitidine was banned?
Carcinogenesis
presence of low levels of an impurity called N-nitrosodimethylamine (NDMA). NDMA is classified as a probable human carcinogen (a substance that could cause cancer) based on animal studies.
Adverse effect of ranitidine?
Why cimetidine banned?
Is cimetidine a drug inducer or drug inhibitor?
Inhibitor
Increase warfarin toxicity
What happens if you give ranitidine injection rapidly?
Bradycardia
Hypotension
So we will never give rapidly
What is prostaglandin analogue?
Misoprostol
NSAID induced peptic ulcer mechanism
NSAID is acidic
So it is unionised in acidic media(stomach)
It is absorbed to parietal cell.
Irritation bleeding perforation korbe
Which is best drug for NSAID induced PUD
Misoprostol
Why misoprostol used in NSAID induced PUD
Prostaglandin improves mucosal blood flow
Inhibits the HCl
Regenerative capacity increase
Secretion barabe
What are the cytoprotective agents?
Mechanism of sucralfate?
Adverse effects of bismuth
Triple therapy with dose?
PPI continue korba kotodin?(in triple therapy)
4-6 wk
Name laxatives with classification
A patient has came with constipation which drug is given?
Firstly non pharmacologic approach
Then laxative
Mechanism of ispaghula husk
Adverse effects of ispaghula husk
Contraindications of ispaghula husk
Mechanism of lactulose?
Adverse effect of lactulose?
Indication of lactulose?
Contraindications of lactulose?
Enema kkhn use korbo?
What are the anti emetics?
A patient with hyperemesis in 1st trimester,what will you give?
Cyclizine,meclizine
What will you give in nausea vomiting motion sickness?
Scopolamine
Cyclizine
Meclizine
Promethazine
Cancer chemotherapy patient hole ki DBA?
Ondansetron oi group
Indication of metoclopramide?
Why metoclopramide given in post partum lactation instead of domperidone?
BBB and placenta cross
Which antiemetic cause extra pyramidal syndrom?
Metoclopramide mechanism
Ondansetron,granisetron indication
Mechanism of ondansetron
Where is chemoreceptor trigger zone?inside BBB or outside?
BBB cross kore na amn drug a emesis hoy?
Ha hote pare..Karon chemoreceptor trigger zone BBB er baire thake
Name drugs for IBS?
What is the role of TCA in IBS ?
What are the drugs for IBD ?
What are the drugs given in diarrhea?
Why loperamide is used instead other opioid?
Composition of ors ?
Role of glucose in ORS?
