Intro

Question 1

what is peptic ulcer disease?

Answer 1

peptic ulcer diseases are chronic ulcerative lesions that occur in any part of the Gastro intestinal tract exposed to aggressive action of acid peptic juices.

Question 2

what are the acid peptic diseases

Answer 2

peptic ulcer disease
Gastro esophageal reflux disease stress related ulcer

Question 3

Pathogenesis

Answer 3

imbalance between defensive factors and aggressive factors of GIT

Question 4

what are the defence mechanism

Answer 4

surface mucus secretion
Bicarbonate secretion into mucus increased mucocell blood flow that washes out H+
apical surface membrane transport regenerative capacity of lining epithelium elaboration of prostaglandin that increases mucus secression blood flow epithelial regeneration

Question 5

what are the damaging forces

Answer 5

gastric acidity
pepsin
b i l e
n s a i d
steroid
cigarette
alcohol
deodeno- gastric Reflux
Helicobactor pylori

Question 6

cause of p u d

Answer 6

helicobacter pylori
n s a i d
increased gastric HCL secretion
inadequate mucosal defence against HCL

Question 7

Physiology of acid secretion

Question 8

Common sites for peptic ulcer

Answer 8

first part of duodenum stomach
Gastro esophageal Junction
within the margins of a Gastro-jejunostomy
throughout the GIT in zollingar Ellison syndrome
within or adjacent to illial meckels diverticulum