Ischemic Heart Disease Flashcards
Drugs used for Pharmacologic Stress Test
Dobutamine
Adenosine
Dipyridamole
Target LDL level for patients with CAD
<100mg/dL
Target LDL level for patients with DM
<70mg/dL
First line drugs for Chronic Coronary Syndrome
Beta Blockers and/or CCB
Risk Factors for IHD
Male > 45, Female > 55, HTN, DM, Dyslipidemia, Obesity, Smoking, Physical Inactivity, Family History of Premature CAD
Anginal Equivalents
Dyspnea, Fatigue, Faintness especially in elderly, women, diabetic
Canadian CVS Society Functional Classification of Angina
I - no limitation
II - slight limitation
III - marked limitation
IV - Inability to carry on any physical activity without discomfort
Patient experiences angina after walking two blocks on the level or after climbing more than one flight of stairs in normal condition. What functional classification?
FUNCTIONAL CLASS III
Second Line Anti-Anginal Drugs
Nitrates Ivabradine Nicorandil Trimetazidine Ranolazil
When to send a patient with coronary angiogram?
- Stress Test negative or nondiagnostic with persisting angina
- Patients whose career involves safety of other with questionable symptoms
- AS or HCM with angina
- For Cardiac operation + Age
- After MI
- High Risk
- Nonatherosclerotic cause of MI
- Maximal therapy not effective
- EF<40% IHD not ruled out
Blood flow reduced at
50% stenosis
Blood flow limited at
80% stenosis
Drugs for Event Prevention in IHD
C. A. S. A. Clopidogrel Aspirin Statins ACEi/ARBs
Indications for CABG
Left Main Coronary Artert
3 vessel disease + LVEF<50% OR DM
2 vessel disease that includes Left Descending Coronary Artery
MI Classification
1 Spontaneous 2 Secondary to Ischemia 3 Biomarkers unavailable 4a PCI related 4b Stent Thrombosis related 5 CABG related
ECG findings in STE-ACS
ST Elevation >=2mm on V1-V6 or >=1mm in limb leads
ECG Findings in NSTE-ACS
ST Depression >=1mm in any leads or T Wave inversion of at least 5mm
LAD supplies leads?
V1, V2, V3, V4
LCX supplies leads?
V5-V6, Inferior II, III, AVF (10%), High Lateral I, AVL
Biomarker best for detecting re infarction?
CKMB
TROPONINS can be detected for up to how many days?
Elevated up to 7-10 days
CKMB can be detected up to how many days?
1 - 2 days
Management for STE-ACS
Urgent revascularization via Thrombolysis and PCI
Management for NSTE-ACS
Primarily medical
High risk factors that warrant invasive management for NSTE-ACS
Refractory chest pain Persistent ST Deviation Ventricular Tachycardia Hemodynamic Instability Signs of Heart Failure
In NSTE-ACS, chest pain is severe and has one of the following (3):
crescendo pattern recent onset (<2 weeks) occurring at rest or minimal exertion, lasting >10mins.
TIMI Scoring for NSTE-ACS
K. A. C. A. S. E. S. (1 point each) Known CAD Aspirin use within 7 days CAD Risk Factors >=3 Age >=65 Severe Angina in last 24 hours Elevated biomarkers ST Deviation >0.5mm
High Risk if >=3 points
First cardiac marker to rise in ACS
Myoglobin
KILLIP Scoring for STEMI
I - normal BP, no congestion
II - moderate HF, bibasal rales, normal BP
III - Severe HF, midbasal rales, S3&S4, normal BP
IV - shock with SBP < 90, peripheral vasoconstriction, cyanosis
Temporal Stages of STEMI
Acute - <7 days
Healing - 7 to 28 days
Healed - >=29 days
STEMI patient initially seen at PCI-capable hospital. FMC-DEVICE TIME?
<=90 mins.
STEMI Patient initially seen at non-PCI capable hospital. FMC-DEVICE TIME?
<=120 mins.
Clear Contraindications to Thrombolysis in STEMI
A B C H H
Aortic Dissection (Suspected) Bleeding (Active Internal) Cerebrovascular Hemorrhage at any time Hypertension (>180 SBP >110 DBP) non - Hemorrhagic stroke within last year
Most common cause of out of hospital death from STEMI
Ventricular Fibrillation
Most common cause of in hospital death from STEMI
Pump Failure
Most common cause of death within 24 hours of admission
Re - M.I.
If a patient with acute MI presents with new murmur, think of 2 potential conditions:
free septal wall rupture
acute mitral regurgitation
Ventricular Fibrillation/ Pulseless VTach
What will you do?!
SCREAM
Shock - defibrillate (monophasic - 360j, biphasic - 200j)
CPR
Epinephrine - 1mg every 3-5 minutes
Amiodarone - 300mg IV bolus then 150mg
68/M came in for sudden onset of substernal chest pain. ECG revealed inferior wall STEMI without Right Ventricle involvement. Which medications are contraindicated?
Inferior wall STEMI without RV involvement - Beta Blockers
Inferior wall STEMI with RV involvement - Beta Blockers and Nitrates