Ischemic Dx Part 1 Flashcards
Ischemia occurs when there is an imbalance between __________ & __________
Oxygen supply & Demand
Blood flow is regulated by what ratio?
Pressure vs resistance ratio
Oxygen supply is determined by
Blood flow
What pathologies can cause issues with blood vessel radius?
Atherosclerosis
Vascular tone
Endothelial cell dysfunction
Acute Coronary Syndrome includes what?
Unstable Angina
Myocardial Infarction (NSTEMI & STEMI)
Different kinds of Angina
ACS happens when?
Plaque rupture and thrombus formation
ACS severity is determined by what?
The amount of coronary blood flow restriction
Difference between stable vs unstable angina
Stable:
-Lasts 1-15 minutes & goes away with rest
-Occurs when heart is under stress
-Very predictable pattern
Unstable:
-Does NOT go away, is an EMERGENCY
-Occurs when blood flow is suddenly slowed
-Very unexpected
Explain development from ischemia to infarct
Ischemia:
-Occurs once there is a decrease in blood supply to myocardial tissue
Injury from severe/prolonged Ischemia:
-damage to myocardial tissue is still reversible if get proper reoxygenation- if not, it becomes…
Infarct: Complete absence of blood supply and now myocardial cells will die due to irreversible injury
(DEAD MEAT DONT BEAT)
Acute MI with necrosis of heart suggests it is how old?
<3-5 days old
NSTEMI aka what?
Subendocardial or non-Q wave MI
STEMI aka what?
Transmural/Q wave MI
NSTEMI- what part of the heart does it involve?
SMALL area of subendocardial wall
Can be found in:
LV
Ventricular septum
Papillary muscle
What causes NSTEMI?
LOCALIZED decrease in blood supply from narrowing of a coronary artery
NSTEMI- EKG looks like what?
ST depression +/- T-wave inversion
(It is possible to have no EKG changes)
STEMI- what part of the heart does it involve?
WHOLE THICKNESS of heart muscle wall, described by where it is:
Anterior
Inferior
Lateral
Septal
STEMI is associated with what pathology in a coronary artery?
Atheroscleric plaques which cause COMPLETE occlusion
STEMI- EKG looks like what?
ST elevation +/- Q waves
“Classic Tombstone” look
How are MI’s classified?
Type 1-5
Describe Type 1 MI
Cause: Primary Coronary event (Plaque erosion +/- rupture, fissuring, dissection)
Describe Type 2 MI
Cause: Secondary cause of ischemia (Increased oxygen demand, decreased supply due to coronary spasm, embolism, anemia, arrhythmia, HTN, HoTN)
Describe Type 3 MI
UNEXPECTED CARDIAC DEATH
(Cardiac arrest)
Describe Type 4 MI
Caused by coronary angioplasty or stents
4a) Associated with PCI
4b) Associated with stent thrombosis