Ischaemia Flashcards
What are the main 4 lobes of the brain?
Temporal
Frontal
Parietal
Occipital
What is the function of the temporal lobe?
Primary auditory perception
vision, memeory , l;anguage, emotion
What is the function of the frontal lobe?
control cognitive skills
emotional expression, memory, language
What is the function of the parietal lobe?
processes sensory information
interprets visual information
what is the function of the occipital lobe?
centre of visual processing
What is the function of the circle of willis?
ensure blood flow to brain is maintained, in the evnt obstruction due to injury/disease
What are the 2 cardiac markers of an MI?
Cardiac Troponin I
Cardiac Troponin T
How does t-PA dissolve blood clot?
binds to fibrin on clot surface activates fibrin-bound plasminogen plasmin cleaved from plasminogen associated with the fibrin fibrin broken down by plasmin clot dissolves
what type of molecule is plasmin?
protease
What is a thrombus?
blood clot
Define ischaemic stroke?
an artery outside/leading to the brain becomes blcoked, usually by a blood clot
define haemorrhagic stroke?
bleeding in the brain-> usually due to high bp bursting a small artery
What is the ischaemic cascade?
series of biochemical reactions in brain/aerobic tissue in response to inadequate blood flow (ischaemia)
How can the ischaemic cascade lead to a reperfusion injury?
reperfusion in brain can cause an inflammatory response
phagocytic cells engulf damaged tissue
harmful chemical damage BBB
brain swelling occurs
what is cerebral edema?
brain swelling
