Irritable Bowel Syndrome Flashcards
Definition of IBS
Chronic abdominal pain with altered bowel habits
Rome IV Criteria
chronic abdominal pain at least 1 day per week associated with defication, change in stool frequency, change in stool consistency
Goals of IBS Treatment
improve stool consistency, QOL, pain
Treatments for IBS-C
Lubiprostone, Linaclotide, Plecanatide, Tenapranor, Tegaserod
Tenapranor MOA
Inhibits sodium/proton exchanger to increase H2O secretion
Tenapranor (brand)
Ibsrela
Ibsrela (generic)
Tenapranor
Tegaserod (brand)
Zelnorm
Zelnorm (generic)
Tegaserod
Tegaserod side effects
increased cardiac events
Tegaserod MOA
5-HT4 agonist
Treatments for IBS-D
Rifaximin, Eluxadoline, Alosetron
Rifaximin MOA
poorly absorbed antibiotic. used to treat if there is a possibility of bacterial overgrowth
Rifaximin duration of treatment
14 day course (can be repeated twice)
Rifaximin (brand)
Xifaxin
Xifaxin (generic)
Rifaximin
Eluxadoline (brand)
Viberzi
Viberzi (generic)
Eluxadoline
Eluxadoline MOA
µ/gamma/K receptor agonist inhibiting bowel contraction
Eluxadoline side effects
constipation & nausea;
contraindicated in: pancreatitis, without a gall bladder, more than 3 alcoholic drinks per day
Alosetron (brand)
Lotronex
Lotronex (generic)
Alosetron
Alosetron MOA
increases H2O reabsorption
Alosetron side effects
REMS: Severe constipation, ischemic colitis
Alosetron duration of treatment
d/c in 4 weeks if no improvement is seen
Treatments for IBS-M
Antidepressants, SOLUBLE Fiber, Peppermint Oil, Antispasmodics
Antispasmodics therapeutic effect
less cramping
