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PHM 604 GI Opth Derm Nutrition > Irritable Bowel Syndrome > Flashcards

Irritable Bowel Syndrome Flashcards

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Dermatology Board Prep flashcards
1
Q

Definition of IBS

A

Chronic abdominal pain with altered bowel habits

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2
Q

Rome IV Criteria

A

chronic abdominal pain at least 1 day per week associated with defication, change in stool frequency, change in stool consistency

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3
Q

Goals of IBS Treatment

A

improve stool consistency, QOL, pain

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4
Q

Treatments for IBS-C

A

Lubiprostone, Linaclotide, Plecanatide, Tenapranor, Tegaserod

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5
Q

Tenapranor MOA

A

Inhibits sodium/proton exchanger to increase H2O secretion

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6
Q

Tenapranor (brand)

A

Ibsrela

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7
Q

Ibsrela (generic)

A

Tenapranor

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8
Q

Tegaserod (brand)

A

Zelnorm

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9
Q

Zelnorm (generic)

A

Tegaserod

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10
Q

Tegaserod side effects

A

increased cardiac events

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11
Q

Tegaserod MOA

A

5-HT4 agonist

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12
Q

Treatments for IBS-D

A

Rifaximin, Eluxadoline, Alosetron

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13
Q

Rifaximin MOA

A

poorly absorbed antibiotic. used to treat if there is a possibility of bacterial overgrowth

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14
Q

Rifaximin duration of treatment

A

14 day course (can be repeated twice)

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15
Q

Rifaximin (brand)

A

Xifaxin

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16
Q

Xifaxin (generic)

A

Rifaximin

17
Q

Eluxadoline (brand)

A

Viberzi

18
Q

Viberzi (generic)

A

Eluxadoline

19
Q

Eluxadoline MOA

A

µ/gamma/K receptor agonist inhibiting bowel contraction

20
Q

Eluxadoline side effects

A

constipation & nausea;
contraindicated in: pancreatitis, without a gall bladder, more than 3 alcoholic drinks per day

21
Q

Alosetron (brand)

A

Lotronex

22
Q

Lotronex (generic)

A

Alosetron

23
Q

Alosetron MOA

A

increases H2O reabsorption

24
Q

Alosetron side effects

A

REMS: Severe constipation, ischemic colitis

25
Q

Alosetron duration of treatment

A

d/c in 4 weeks if no improvement is seen

26
Q

Treatments for IBS-M

A

Antidepressants, SOLUBLE Fiber, Peppermint Oil, Antispasmodics

27
Q

Antispasmodics therapeutic effect

A

less cramping

PHM 604 GI Opth Derm Nutrition (4 decks)

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