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PHM 604 GI Opth Derm Nutrition > Constipation > Flashcards

Constipation Flashcards

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Dermatology Board Prep flashcards
1
Q

Medication causes of constipation

A

opioids, anti-cholinergics, iron, calcium channel blockers

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2
Q

general causes of constipation

A

Low fiber / low H2O; Comorbidities (pregnancy, IBS, hypothyroidism)

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3
Q

General approach to constipation (acute vs. chronic)

A

acute - osmotic, stimulant
chronic - bulk forming (can use osmotic, or stimulant as needed)

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4
Q

PEG 3350 MOA

A

Inert solute that pulls water into the colon

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5
Q

Lactulose MOA

A

non absorbed sugar syrup which pulls water into the colon

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6
Q

PEG 3350 (class)

A

osmotic

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7
Q

Lactulose (class)

A

osmotic

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8
Q

Lubiprostone MOA

A

acts on Cl- channels to pull water into GI tract

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9
Q

Lubiprostone side effects

A

Nausea & diarrhea

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10
Q

Linaclotide (brand)

A

Linzess

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11
Q

Linzess (generic)

A

Linaclotide

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12
Q

linaclotide MOA

A

increases Cl- and bicarb secretion into stool

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13
Q

linaclotide side effects

A

diarrhea

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14
Q

plecanatide (brand)

A

trulance

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15
Q

trulance (generic)

A

plecanatide

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16
Q

plecanatide MOA

A

increases Cl- and bicarb secretion into stool

17
Q

plecanatide side effects

A

diarrhea

18
Q

treatments for opioid induced constipation

A

start with osmotic lax (may need BID over QD)
may need stimulant lax

19
Q

stimulant laxatives side effects

A

cramping

20
Q

laxative that does NOT help with opioid induced constipation

A

docusate

21
Q

Rx treatments for opioid induced constipation

A

µ receptor antagonists

22
Q

µ receptor antagonist examples

A

methylnatrexone
naloxegol
naldemidine
lubiprostone

PHM 604 GI Opth Derm Nutrition (4 decks)

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