Iron and Porphyrin Flashcards
function of hemoglobin
transport oxygen
function of myoglobin
store oxygen
function of cytochromes, flavoproteins
electron transport
function of catalase, peroxidase
enzymatic function
water soluble complex of ferric salt and a protein, apoferritin
ferritin
transports the iron from hgb broken down by macrophages to normoblasts for production of new hemoglobin
transferrin
most frequent micronutrient deficiency
iron deficiency
stages of iron deficiency
depletion, deficient erythropoiesis, deficiency anemia
- iron is mobilized from stores
- plasma ferritin decreases
- iron absorption increases
- increase in TIBC
iron depletion
- iron stores depleted
- plasma iron concentration falls
- lack of iron for heme synthesis
iron deficient erythropoiesis
everything low plus anemia
iron deficiency anemia
- iron overload
- inborn error of absorption
- avoid vitamin C (increases ability to absorb iron)
hemochromatosis
amount of free binding sites on transferrin
UIBC
- produced by the liver
- important in recycling Fe
- iron is conserved and removed by Kuppfer cells
Haptoglobin
elevations in porphyrin precursors as well as the porphyrins
neurological/psychiatric