Iron and Bilirubin Flashcards
What is the reference range for iron
8-35 umol/L
What is the reference range for TIBC
40-75 umol/L
What is the reference range for saturation index
Female: 0.12-0.60
Male: 0.10-0.55
What is the reference range for ferritin
Female: 20-300 ug/L
Male: 30-500 ug/L
What is the reference range for total bilirubin
<20 umol/L
What is the reference range for Transferrin
1.8-3.5 g/L
What is the reference range for conjugated bilirubin
<7 umol/L
What causes increased serum iron
hemochromatosis
iron medications
hormonal contraceptives
aplastic anemia
What causes decreased serum iron
IDA
hemorrhage
menstruation
medication
anemia of chronic disease
What causes increased TIBC
IDA
pregnancy
oral contraceptives
What causes decreased TIBC
chronic inflammatory disease
malignancy
hemochromatosis
What is ferritin
the major storage form of iron
What causes increased ferritin
malignancies
chronic infections
hemochromatosis
chronic inflammatory diseases
hepatitis
What causes decreased ferritin
IDA
What is transferrin
carries ferric iron in the blood
What causes increased transferrin
pregnancy
administration of estrogen
iron deficiency
What causes decreased transferrin
negative APR
decreased synthesis
protein loss
What does an FIT test detect
hemoglobin in feces for screening for colorectal cancer
What is bilirubin
a degradation product of heme
What are interferences with bilirubin testing
lipemia, hemolysis, light exposure
What is a critical result for neonatal jaundice
> 300 umol/L in children <30 days old
What is pre-hepatic
hemolytic anemia may produce more bilirubin than the lover can process
What are the expected lab results for pre-hepatic
increased total bili
increased unconj bili
normal conj bili
neg urine bili
What is hepatic
damage to the hepatocytes or inherited disorders result in the inabiity to conjugate or excrete conjugated bilirubin or inability to take up unconjugated bilirubin for conjugation and excretion
What are the expected lab results for hepatic
increased total bili
variable everything else
What is post-hepatic
gallstones, spasms or neoplasms may prevent bilirubin-glucuronide from reaching the intestine
What are the expected lab results for post-hepatic
increased total bili
normal unconj bili
increased conj bili
pos urine bili
What is crigler-najjar syndrome type 1
absense of UDP-glucuronyltransferase resulting in high concentrations of unconjugated bilirubin
What is crigler-najjar syndrome type 2
result of a partial deficienct in UDP-glucuronyltransferase, normal life is expected with treatment of phenobarbital
What is dubin-johnson sundrome
elevated levels of conjugated bilirubin with only a slight increase in unconjugated bilirubin
What is gilbert syndrome
mild unconjugated hyperbilirubinemia
What is lucey-driscoll syndrome
unconjugated bilirubin levels are increased
