Iron and Bilirubin

Question 1

What is the reference range for iron

Answer 1

8-35 umol/L

Question 2

What is the reference range for TIBC

Answer 2

40-75 umol/L

Question 3

What is the reference range for saturation index

Answer 3

Female: 0.12-0.60
Male: 0.10-0.55

Question 4

What is the reference range for ferritin

Answer 4

Female: 20-300 ug/L
Male: 30-500 ug/L

Question 5

What is the reference range for total bilirubin

Answer 5

<20 umol/L

Question 5

What is the reference range for Transferrin

Answer 5

1.8-3.5 g/L

Question 6

What is the reference range for conjugated bilirubin

Answer 6

<7 umol/L

Question 7

What causes increased serum iron

Answer 7

hemochromatosis
iron medications
hormonal contraceptives
aplastic anemia

Question 8

What causes decreased serum iron

Answer 8

IDA
hemorrhage
menstruation
medication
anemia of chronic disease

Question 9

What causes increased TIBC

Answer 9

IDA
pregnancy
oral contraceptives

Question 10

What causes decreased TIBC

Answer 10

chronic inflammatory disease
malignancy
hemochromatosis

Question 11

What is ferritin

Answer 11

the major storage form of iron

Question 12

What causes increased ferritin

Answer 12

malignancies
chronic infections
hemochromatosis
chronic inflammatory diseases
hepatitis

Question 13

What causes decreased ferritin

Answer 13

IDA

Question 14

What is transferrin

Answer 14

carries ferric iron in the blood

Question 15

What causes increased transferrin

Answer 15

pregnancy
administration of estrogen
iron deficiency

Question 16

What causes decreased transferrin

Answer 16

negative APR
decreased synthesis
protein loss

Question 17

What does an FIT test detect

Answer 17

hemoglobin in feces for screening for colorectal cancer

Question 18

What is bilirubin

Answer 18

a degradation product of heme

Question 19

What are interferences with bilirubin testing

Answer 19

lipemia, hemolysis, light exposure

Question 20

What is a critical result for neonatal jaundice

Answer 20

> 300 umol/L in children <30 days old

Question 21

What is pre-hepatic

Answer 21

hemolytic anemia may produce more bilirubin than the lover can process

Question 22

What are the expected lab results for pre-hepatic

Answer 22

increased total bili
increased unconj bili
normal conj bili
neg urine bili

Question 23

What is hepatic

Answer 23

damage to the hepatocytes or inherited disorders result in the inabiity to conjugate or excrete conjugated bilirubin or inability to take up unconjugated bilirubin for conjugation and excretion

Question 24

What are the expected lab results for hepatic

Answer 24

increased total bili
variable everything else

Question 25

What is post-hepatic

Answer 25

gallstones, spasms or neoplasms may prevent bilirubin-glucuronide from reaching the intestine

Question 26

What are the expected lab results for post-hepatic

Answer 26

increased total bili
normal unconj bili
increased conj bili
pos urine bili

Question 27

What is crigler-najjar syndrome type 1

Answer 27

absense of UDP-glucuronyltransferase resulting in high concentrations of unconjugated bilirubin

Question 28

What is crigler-najjar syndrome type 2

Answer 28

result of a partial deficienct in UDP-glucuronyltransferase, normal life is expected with treatment of phenobarbital

Question 29

What is dubin-johnson sundrome

Answer 29

elevated levels of conjugated bilirubin with only a slight increase in unconjugated bilirubin

Question 30

What is gilbert syndrome

Answer 30

mild unconjugated hyperbilirubinemia

Question 31

What is lucey-driscoll syndrome

Answer 31

unconjugated bilirubin levels are increased