Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Chemistry > Iron > Flashcards

Iron Flashcards

You may prefer our related Brainscape-certified flashcards:
AP® Chemistry flashcards Periodic Table flashcards Chemistry 101 flashcards Organic Chemistry 101 flashcards
1
Q

Gut Involvement in Iron Metabolism

A

Decrease stomach pH solubilizes Fe-containing compounds
Transport molecules facilitate absorption into blood

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Blood Involvement of Iron Metabolism

A

Fe3+ bound to Transferrin and transported to tissues
- Maintains solubility
- Keeps Fe unreactive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Cells Involvement with Iron Metabolism

A

Transferrin endocytosis is receptor mediated
Results in Fe3+ release
Fe distributed in cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Usage of Iron in Cells

A

Protein components (Heme)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Storage of Iron in Cells

A

Ferritin (Fe2+)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Excess Iron in cells

A

Causes toxicity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Normal Iron Ranges

A

55-160 ug/dL (Male)
40-155 ug/dL (Female)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Total Iron Binding Capacity

A

Sites on transferrin saturated with iron
Reference range: 255-450 ug/dL

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

Percent transferrin saturation

A

20-50%

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Increased Total Iron Binding Capacity

A

Situations that cause increase in transferrin
- Late pregnancy
- Iron deficiency anemia (compensation)
- Acute hemorrhage
- Acute destruction of liver cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

Decreased Serum Iron

A

Dietary deficiency or malabsorption
Loss of iron (blood loss or late pregnancy)
Impaired release of stored iron

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Decreased Total Iron Binding Capacity

A

Decreased synthesis of Transferrin
Increased loss of protein as in renal disease

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

Total Serum Iron Principle of Assay

A

Dissociate ferric iron from transferrin and reduce to ferrous form
Iron + Color Reagent = Color Change

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

TIBC Principle of Assay

A

Saturate transferrin with ferric iron
Remove excess free iron from reaction tube
Dissociate ferric iron from transferrin and reduce to ferrous form
Measure iron as in total serum iron procedure

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Calculation for % Saturation

A

(Serum Iron/TIBC) x 100

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Other forms of Iron

A

Ferritin
Transferrin
Hemosiderin
Hemochromocytosis

17
Q

Ferritin

A

Tissue Storage form
Sensitive indicator of Iron Deficiency Anemia

18
Q

Transferrin

A

Transport molecule for iron

19
Q

Hemosiderin

A

Insoluble iron deposits in tissue and bone marrow

20
Q

Hemochromocytosis

A

Excess iron deposition in tissues
Defective iron control
Multiple transfusion

21
Q

Ceruloplasm

A

Alpha-2-glycoprotein
Enzyme with 6 Cu atoms
Carries >95% of total Cu in plasma
Participates in conversion of ferrous iron to ferric iron
Works in association with transferrin after release from RES

22
Q

Wilson’s Disease

A

Autosomal recessive disorder
Causes Cu buid-up in tissues
Genetic defect of Cu-ATPase ATP7B
Cu incorporation into ceruloplasmin is diminished

23
Q

Wilson’s Disease Symptoms

A

Cirrhosis
Kayser-Fleischer rings in cornea
May cause brain and kidney damage from Cu deposition

24
Q

Kayser-Fleischer rings

A

Ring of golden-brown or brownish-green pigment behind the limbic border of cornea

25
Q

Porphyrin Derivatives

A

4 Tetrapyrrole ring linked by methane bridges

26
Q

Oxidative compounds of Porphyrins

A

Hemoglobin
Myoglobin
Vitamin B12
Chlorophyll
Cytochromes

27
Q

Porphyrin ring

A

Metal chelates
Hgb = Iron
Myoglobin = Iron
Vit B12 = Cobalt
Chlorophyll = Magnesium
Cytochromes = Cu & Fe

28
Q

Three Clinically Significant Porphyrins

A

Uroporphyrins (URO)
Coprophyrins (COPRO)
Protoporphyrins (PROTO)

29
Q

Uroporphyrins

A

8 Carboxyl groups
Highly soluble because of large number of -COOH side chains
Excreted primarily in urine
Soluble in blood & tissues

30
Q

Coproporohyrins

A

4 carboxyl groups
Demonstrates intermediate solubility
Excreted primarily in feces but also appears in urine

31
Q

Protoporphyrins

A

2 carboxyl groups
Least soluble
Located primarily within erythrocytes
Excreted only in feces
Most soluble in lipid solvents

32
Q

Biosynthesis of Porphyrins

A

Intermediate products in heme biosynthesis
Have no role in body function in free form
Appear in tissue and body fluids only as an abnormality in enzyme function

33
Q

Lead Toxicity

A

Binds to any compound with a sulhydryl group
Inhibits multiple enzymes in heme biosynthesis
Get elevations in delta ALA

34
Q

Lead Toxicity Test

A

Whole blood screening is the test of choice
Hair analysis for lead concentration is alternative marker for exposure

35
Q

Other heavy metals & organic solvents poisoning

A

Have been associated with porphyria

Chemistry (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions