Iron Flashcards
What are the Regulatory Peptide hormone?
Ferroportin
Hepcidin
hormone that regulates or promotes exportation of iron from the cells
Ferroportin
regulates the iron absorption in the upper GIT by modulating the activity of ferroportin
Hepcidin
T/F. Serum iron levels are falsely elevated by hemolysis and affected by diurnal variation
True
T/F. Diurnal variation means higher (morning), night (low), *false decreased at night
True
Increase level on:
○ Iron poisoning (overdose)
○ Hemochromatosis, opposite of IDA - high in the pancreas, could also cause DM
○ Viral Hepatitis
○ Non-Iron deficiency anemias (increased iron level in the plasma)
Non-Iron deficiency anemias (increased iron level in the plasma):
■ Thalassemia
■ Aplastic anemia
■ Megaloblastic anemia
■ Sideroblastic anemia
■ Hemolytic anemia
■ Pernicious anemia
Decreased level on:
○ IDA - most common anemia (pediatric or kids)
○ Malnutrition
○ Malignancy (cancers)
○ Chronic infection
○ Nephrotic syndrome
It refers to the amount of iron that could be bound by saturating transferrin and other minor-iron binding proteins present in the serum or plasma sample
Total Iron Binding Capacity
T/F. Serum iron and TIBC are inversely proportional
True
Used to differentiate different types of anemia:
■ IDA
■ Non-IDA
high TIBC, low iron level
IDA
low TIBC, high iron level
Non-IDA
Formula:
■ TIBC = UIBC + Serum Iron
■ TIBC (ug/dL) = Serum
transferrin (mg/dL) x 1.2521
IDA. hepatitis, iron-supplemented pregnancy
Increased
non-IDA and nephrosis
Decreased
Measure of the reserve iron-binding capacity
transferrin
● Formula:
Unsaturated Iron Binding Capacity (UIBC)
Formula: TIBC - Serum iron
● An index or iron storage. It is also known as transferrin saturation.
● It is the ratio of serum iron to TIBC.
Percent Saturation
T/F. Serum iron and percent saturation are directly proportional
True
Percent Saturation Increased in:
iron overdose, hemochromatosis, sideroblastic anemia, non-IDA anemia (megaloblastic anemia, pernicious anemia…)
Percent Saturation Decreased in:
IDA, malignancy, Chronic infection, anemia of chronic dse.
Percent Saturation Formula:
% saturation = Total iron (ug/dL) x100
TIBC (ug/dL)
The condition where percent saturation is at
its lowest
IDA
● Transferrin in the principal iron transport protein
● Formula:
Serum Transferrin
Formula: TIBC (ug/dL) x 0.70 = mg/dL
