Ionotropic Receptors II

Question 1

types of cholineterases and their functions

Answer 1

acetlycholinesterase and plasma cholinesterases aka pseudo or buturylcholinesterase

catalase the hydrolysis of acetylcholine to acetic acid and choline

Question 2

the two active sites of cholinesterases

Answer 2

anionic and esteratic site

Question 3

short acting anticholinesterases

Answer 3

repsectively ammonium alochols

bind to the anionic site of cholinesterases

competively displace acetlcholine from rhe active site

Question 4

medium acting anticholinesterases

Answer 4

interact witht eh esteractic site to give a carbomylated product

the carbamylated enzyme is hydroxylated more slowly

Question 5

long acting (irreversible) anticholinesterases and industrial examples

Answer 5

phosphorlates the serine hydroxyl group of the esteractic site

insecticides parathion and chemcial weapons sarin gases

Question 6

uses of anticholinesterases

Answer 6

used for treating mystenia gravis (neostigmine)

and used to treat alzheimers (donepezil)

Question 7

actions od muscarinic receptor agonists (rest and digest)

Answer 7

smooth muscle contractions in the gut and bladder m3 muscarinic receptors

pupillary constriction with cilliary muscle contraction

decreased rarete and force of contraction of the heart

increase glandular secretion, saliva sweat and pancreas m3

Question 8

muscarinic antagonists causes

Answer 8

ingibtions of secreations

increase heart rate

pupillary dilation

anti- parkinsons action

anti-emetics