Ionotropic Receptors Flashcards
what do mechanically gated ion channels respond to
pressure
what are ionotropic receptors
they are ligand gated ion channles
ionotropic recepetors are membrane bound receptor proteins
when lignas binds thry open and allow ions such as na+, k+, ca2+ or cl-
this flow of ions can either casue depolarization for a excitatory response or a hyperpolarozation for an inhibitory response
p2x receptors
respomds to atp and adp
involves in contraction in smooth muscle and platelet aggeregation
two neurons in series of the autonomic nervous system
pre-ganglionic and post ganglionic
synapse which is the gap is known as the ganglion
post-ganglionic nerves are not myelinated
main sympathethic effects
release noradrenaline and adrenaline neurotransmitters
increases heart rate, bronchioles dilate and blood glucose concentration increases
gastrointestinal molity decreases
main parasympathetic effects
release of acetlycholine
decreases of heart rate dilares visceral blood vesselsa and increases digestive activity
relaxation of sphicnters and allows for urination by contraction the detrusor muscle
contract cilliary muscles in the eyes
nicotinic receptors
they are ionotropic and embedded in the cell membrane
protein with five subunits two alphas, beta, gamma and epsilon
either a tetrametric or pentameric assembly