Investigations

Question 1

Peripheral blood cell markers

1. Indication
2. Dx to r/o

Answer 1

1. Pancytopenia, lymphadenopathy

2. Lymphoma

Question 2

PNH cell markers

1. PNH
2. Characteristics
3. Epidemiology
4. Close relationship
5. Median survival
6. Etiology
7. Dx

Answer 2

1. Paroxysmal nocturnal hemoglobinuria: Acquired, life-threatening disease of blood.
2. Hemolytic anemia, thrombosis, & impaired BM function
3. Typically young adults with median age of 35-40 years.
4. Aplastic anemia in 20-30% of PNH patients.
5. 10 years after Dx.
6. Genetic mutation in PIG-A in BM stem cell.
7. Flow cytometry is gold standard.