Introductory therapeutics

Question 1

Some drugs part of Pfizer…

Answer 1

Zoloft - antidepressant
Viagra - happy man pills
Zyrtec - antihistamine

Question 2

A majority of the top 10 drugs in Australia are what?

Answer 2

cholesterol-lowering - statins
antacids - omeprazole
antipsychotic - olanzapine
asthma - salmeterol
NSAIDS - celecoxib, rofecoxib
insulin

Question 3

Some of the top 10 drugs by prescription…?

Answer 3

cholesterol-lowering - statins
antibiotics - Amoxycillin
antacids - omeprazole
ACE inhibitors - perindopril
diabetic drugs - metformin

Question 4

Properties of penicillin G… problem & solution

Answer 4

problem: time-dependent killing but short half-life (1 hour)
solution: addition of poorly soluble salts -> slows absorption rate

Question 5

What kills >16k Nth Americans each year?

Answer 5

NSAIDS

Question 6

When did modern pharmacology start?

Answer 6

1960’s

Question 7

What does post hoc ergo propter hoc mean?

Answer 7

he was sick, he is now well, and therefore the treatment cured him

Question 8

How did organic chemistry revolutionise drug development? eg?

Answer 8

by designing and making fully synthetic drugs
eg fluoroquinolone (antibiotic)

Question 9

What drug concentrations are desired for efficacy?

Answer 9

those that fall in the therapeutic window

Question 10

What do in vitro dose response studies tell us?

Answer 10

what concentration of drug is needed

Question 11

A bit about acepromazine (ACP)…

Answer 11

• phenothiazine tranquiliser in vet med

- general sedation & preanaesthetic agent