Introductory (1.1) Flashcards

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1
Q

What is the cell theory?

A

A scientific theory that states all living organisms are:

1 - Composed of one or more cells — cells are building blocks of organisms;

2 - A cell is the smallest unit of life — that is, a cell is the most basic unit capable of carrying out all the functions of a living organism;

3 - Cells come from pre-existing cells (Omni cellulae e cellula) – that is, cells do not show spontaneous generation.

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2
Q

What made the development of the cell theory possible?

A

Advances in microscopy. As the quality of light microscopes improved, more and more information about the structure of organisms and cells was collected.

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3
Q

Divide these into living and non-living: Animals, Plants, Bacteria, Viruses, and Fungi.

A

Animals, Plants, Bacteria, Fungi: living
Viruses: non-living

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4
Q

How are cells formed?

A

They don’t spontaneously appear; they are always formed by the division of preexisting cells

(Prokaryotic cells divide by binary fission, while eukaryotic cells can divide through fission, mitosis, or meiosis)

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5
Q

Outline evidence that supports the cell theory.

A

No evidence proves the cell theory to be incorrect.

Subcellular components have never been seen to perform the functions of life, whereas full cells have.

From the 17th century on, biologists examined tissues from plants and animals (later from fungi, bacteria, and protists) and saw that every specimen contained at least one or more cells.

We have observed cells coming from other cells but never observed spontaneous generation.

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6
Q

What is the difference between theory in daily use and scientific environments?

A

In daily use: there are doubts, a guess

Scientific: a theory is true through repeated observations and experiments. There is no current doubt. As of yet, no evidence has been collected that does not support the idea.

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7
Q

Describe the features of striated muscle fibers that make them a discrepancy from a typical cell.

A

Striated muscle fibers are large cells that have multiple nuclei (while most eukaryotic cells have one nucleus, each cell is multinucleated, and the average muscle fiber cell is about 30 mm long, which is much larger than a typical cell).

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8
Q

Describe features of red blood cells that make them a discrepancy from a typical cell.

A

Red blood cells have no nucleus (while most eukaryotic cells have one nucleus).

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9
Q

Describe features of aseptate fungal hyphae that make them a discrepancy from a typical cell.

A

Aseptate fungal hyphae are tube-like structures that contain no cell membranes between the many nuclei.

Aseptate hyphae are not divided up into individual cells, resulting in a continuous cytoplasm along the length of the hyphae.

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10
Q

Describe features of giant algae (acetabularia) that make them a discrepancy from a typical cell.

A

Giant algae can be a large, single-celled organism with a single nucleus.

Organisms as large as giant algae would be expected to be multicellular, but they have only one cell with one nucleus.

As a single-celled organism, Acetabularia challenges two widely accepted notions about cells: that they must be simple in structure and small in size.

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11
Q

Outline the functional characteristics of life.

A

1) All life has a cellular structure (according to the cell theory, all living things are composed of cells).
2) All life exchanges energy and matter with the environment (including intake of nutrients and excretion of waste).
3) All life has a metabolism (chemical reactions within the organism).
4) All life can recognize and respond to changes in environmental conditions.
5) All living things can grow and/or develop through the lifespan (increase in size, mass, or number of cells within the organism)
6) All life has the capability for reproduction (production of similar cells/organisms from existing ones).
7) All life has maintenance of homeostasis (regulating for a stable interior environment).
8) At the population level, life adapts and changes over time.

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12
Q

Why are viruses not considered living organisms?

A

A single living cell is capable of carrying out all life functions. In contrast, a virus is a non-living example because it cannot carry out all the processes of life. A virus has a protein coat and, like living organisms, has genetic material (DNA or RNA). However, viruses do not metabolize or reproduce – this function is carried out by the infected host cell. Because they exhibit no properties of life outside the host cell and do not have a cellular structure, viruses are not regarded as living entities.

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13
Q

1 um = ?nm
1000 um =?mm

A

1000 nm (nanometres) = 1 μm (micrometre)

1000 μm (micrometres) = 1 mm (millimetre)

(The size of a typical animal cell ranges from 10 to 20 μm in diameter.)

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14
Q

Describe the “SAM” Triangle

A
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15
Q

Why can’t a cell just keep growing?

A

Just like a balloon, as a cell grows, its volume increases much more than the surface area in the cell. To survive, a cell needs to import molecules and expel waste products through its plasma membrane. If a cell’s surface area is too small compared to its volume, not enough of the necessary molecules can get in, and not enough waste (including heat) can get out.

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16
Q

What is the ratio between Volume and Surface Area (SA:V)?

A

While volume increases cubically, the surface area increases quadratically.

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17
Q

Cite cell adaptations that can occur to provide more surface area for faster exchange of material.

A

1 - The folds in a human brain increase the surface area and allow more brain tissue to fit in a smaller area;
2 - The small intestine has small folds that increase the surface area exposed to the digested food. These folds are called villi and are where nutrients are absorbed in the body. The villi increase the surface area and allow more absorption to take place. Additionally, the cells making up the villi have microvilli, which are small folds on their cell membranes that increase the surface area even more. This allows nutrients to be absorbed more efficiently.

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18
Q

Outline the activities occurring in the volume of the cell.

A

The cell volume is full of cytoplasm in which many metabolic reactions are occurring. The metabolic reactions require reactants (i.e. nutrients and oxygen) and may produce waste (i.e. urea and CO2).

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19
Q

Outline the activities occurring at the surface of the cell.

A

The cell surface area is the cell membrane, through which reactants and waste enter and leave the cell.

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20
Q

Calculate the surface area, volume, and SA:V ratio of a cube.

A

Surface area= side length^2
Volume= side length^3
SA:V ratio = [length^2 / length^3]

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21
Q

Explain the benefits and limitations of using cubes to model the surface area and volume of a cell.

A

Cubes are often used to model cell size because they can be manipulated, visualized, and easily measured. However, cells are not cubic, cells are more difficult to manipulate and measure because of their microscopic size. Luckily, the relationship between surface area and volume is the same in both cubes and cells.

22
Q

Describe the relationship between cell size and the SA:V ratio of the cell.

A

If cell size increases, the surface area to volume ratio decreases.
This means that with larger cells, there is less surface area relative to the amount of volume.

23
Q

List three adaptations of cells that maximize the SA: volume ratio.

A
  1. Long extensions, such as in neurons.
  2. Thin, flattened shape, such as in red blood cells.
  3. Microvilli, such as in small intestine epithelial cells.
24
Q

What is an emergent property?

A

Characteristics and/or abilities that only arise from the interaction of the parts of a structure.

25
Q

What is the difference between multicellular & unicellular organisms?
Give examples

A

Multi: +1, Human, turtle, plants
Uni: 1, bacteria, paramecium, yeast, amoeba

26
Q

When can you identify when something has emergent properties?

A

Emergence occurs when an entity is observed to have properties its parts do not have on their own. These properties or behaviors emerge only when the parts interact in a wider whole.

27
Q

Provide an example of emergent properties at different hierarchical levels of life.

A

Heart cell –> emergent property of life
Heart tissue –> emergent property of synchronized contractions
Heart organ –> emergent property of being able to pump blood

28
Q

Define tissue.​

A

A group of cells that specialized in the same way to perform the same function.

29
Q

Outline the benefits of cell specialization in a multicellular organism.

A

By becoming specialized, cells can be more efficient in their role. They can have particular structures and metabolisms that maximize the function of the cell for a specific purpose.

30
Q

Define differentiation.​

A

The development of specialized structures and functions in cells.

31
Q

Describe the relationship between cell differentiation and gene expression.

A

Differentiation in cells is due to different gene expressions in different cell types.

All cells in a multicellular organism contain the same genes, but different cells will express different genes.

To express a gene means to “switch it on” so that the protein (or other gene product) is made.

32
Q

Define zygote.

A

The cell that results from a sperm fertilizing an egg.

33
Q

Define embryo.

A

Early stages of development after the zygote divides.

34
Q

List two key properties of stem cells that have made them the active areas of research in biology and medicine today.

A

Stem cells can divide repeatedly: useful for the treatment of tissues that have been killed or damaged because they can produce large numbers of identical cells.

Stem cells are not differentiated: they have not “turned off” genes so they can still specialize to produce different cell types and a variety of different tissues.

Because of these two key properties, stem cells are used in medical research and the treatment of diseases.

35
Q

Explain why stem cells are most prevalent in the early embryonic development of a multicellular organism.

A

The cells of the early embryo are the most versatile because they have differentiated the least.

As the embryo develops, the cells gradually become more differentiated.

36
Q

Contrast the characteristics of the embryonic, umbilical cord, and adult somatic stem cells.

A

Embryonic stem cells: the inner cell mass of an embryo can differentiate into any body cell (pluripotent)
Umbilical stem cells: can only differentiate into blood cells (multipotent)
Adult somatic stem cells:found in bone marrow, skin and liver, have limited differentiation ability (multipotent)

37
Q

Define totipotent.

A

A stem cell that can become any body cell (including the placenta in placental mammals).
A zygote is totipotent.

38
Q

Define multipotent.

A

A stem cell that has partially differentiated but can still become multiple, related cell types.
Umbilical cord stem cells are multipotent.

39
Q

Define pluripotent.

A

A stem cell that can become any body cell.
The inner cell mass of a blastocyst is pluripotent.

40
Q

Outline the cause and symptoms of Stargardt’s disease.

A

Stargardt’s disease is a recessive genetic disease that causes light detection cells of the retina to degenerate.

Vision becomes progressively worse and eventually leads to blindness.

41
Q

Explain how stem cells are used in the treatment of Stargardt’s disease.

A

As a treatment, retina cells derived from embryonic stem cells are injected into the eyes.

These cells attach to the retina, divide and differentiate into healthy retinal cells which improves vision.

42
Q

Outline the cause of leukemia.

A

Leukemia is cancer that leads to the uncontrolled division of the cells that create white blood cells.

43
Q

Explain how stem cells are used in the treatment of leukemia.​

A

A person with leukemia is given chemotherapy, which kills the cancer cells.

Then, bone marrow (containing adult stem cells) is transplanted from a donor to the person with leukemia.

The stem cells establish themselves, divide and start to produce new blood cells.

44
Q

Discuss the benefits of using adult stem cells.

A

Can divide endlessly and can differentiate.

Can be used to repair and regenerate tissues.

Can be fully compatible with adult self-donor, so no risk of immune rejection.

Fewer ethical considerations since the creation and/or destruction of embryos are not involved.

Adults can give consent for use of their stem cells.

45
Q

Discuss the drawbacks of using adult stem cells.

A

Hard to find and obtain from the body, and some tissues contain few stem cells.

Multipotent, so limited cell types can be created.

46
Q

Discuss the benefits of using embryonic stem cells.

A

Unlimited division and differentiation potential.

Cells won’t have genetic mutations that have accumulated with age.

47
Q

Discuss the drawbacks of using embryonic stem cells.

A

Risk of becoming tumorous if division can’t be controlled.

Creation and/or destruction of embryos are involved.

48
Q

Discuss the benefits of using cord blood stem cells.

A

Easy to obtain and store.

Cells are compatible with the newborn from which they were acquired (no immune system rejection)

49
Q

Discuss the drawbacks of using cord blood stem cells.

A

Multipotent, so limited cell types can be created.

50
Q

Define magnification.

A

How much larger an object appears compared to its real size

51
Q

Define “field of view.”

A

The diameter of the area is visible through the microscope.

52
Q

Define micrograph.

A

A photograph taken through a microscope to show a magnified image of an item.