Introduction to Solid Dosage Form

Question 1

Dominating tablet processing :

Answer 1

Compression method

Question 2

Tablet can contain…

Answer 2

1 or more API & Series of excipients

Question 3

What are the most common excipient class for tablet?

Answer 3

1. Bulking agent/filler –> Lactose
2. Binder –> starch
3. Lubricant

Question 4

Filler

Answer 4

Lactose
Sucrose
Glucose
Cellulose
Mannitol
Sorbitol
CC

Question 5

Disintegrant

Answer 5

Starch
Cellulose
Sodium Starch Glycolate (SSG)
Sodium Carboxymethylcellulose

Question 6

Solution binder (process: Agglomeration)

Answer 6

Gelatin
Starch
PEG
Sucrose

Question 7

Dry binder

Answer 7

Cellulose
Methylcellulose
PEG

Question 8

Glidant (1 machine to 1 machine )

Answer 8

MgSt
Silica
Talc

Question 9

Lubricant

Answer 9

MgSt
Stearic acid
PEG
SLS
Liq paraffin

Question 10

Antiadherent

Answer 10

MgSt
Talc
Starch
Cellulose

Question 11

Tablets can be classified according to their release profile:

Answer 11

1. Immediate release
2. Modified release

Question 12

Modified release;

Answer 12

–.>Pulsatile release (burst, little by little )
–>Delayed release
–> Prolonged/extended release

Question 13

5 Tablet Quality Attributes:

Answer 13

1. Uniformity of weight
2. Uniformity of content / assay (HPLC)
3. Disintegration
4. Dissolution (USP apparatus I/II)
5. Mechanical strength (hardness / friability )

Question 14

Definiton of powder compression?

Answer 14

The forcing of particles into close proximity to each other by the application of mechanical force

Question 15

Function of excipient ?

Answer 15

1. control biopharmaceutical and quality attributes
2. aid in manufaturing of tablet

Question 16

In the manufacturing of tablets, several technical
problems can arise. Such as ?

Answer 16

1. High weight
2. Dose variation
3. Low mechanical strength
4. Capping
5. Adhesion
6. High friction

Question 17

Important tests of quality attributes of tablets?

Answer 17

1. Disintegration
2. Dissolution
3. Friability
4. Tablet fracture resistance