Introduction to Pharmaceutical Dosage Forms Flashcards
Various dosage forms are named and grouped according to:
- Method of administration
- Method of preparation
- Physical nature
Classification according to method of administration
- Oral DF
- Parenteral DF
- Rectal DF
- Inhalation DF
- Topical DF
Preparations intended to be taken orally
Oral DF
preparations introduces into the body by injections through the skin mucous membranes
Parenteral DF
employed for systemic effect or a local action through the rectum
Rectal DF
intended to be finally dispensed or vaporized to the mucous membranes of the lower part of the respiratory tract
Inhalation DF
intended to be applied on the skin or instilled into the eyes, nose, or ears
Topical DF
Classification of Physical Nature
- Liquids
- Extracts
- Parenteral Preparations
- Intravenous Admixture
- Ophthalmic Preparation(sterile prep for eyes)
- Medicated Applications
- Powders
- Oral Solid DF
- Aerosols
- Radio-pharmaceuticals
- Biological Products
A homogeneous mixture that is prepared by dissolving a solid or liquid or gas in another liquid. It represents a group of preparations in which the molecules of the solute or dissolved substances are dispersed among those of the solvent
Solution (Liquids)
types of solutions
- Aqueous Sol.
- Sweet or Other viscid Aqueous Sol.
- Non-Aqueous Sol.
3 types of liquids
- Solution
- Emulsions
- Suspensions
water is used as the vehicle or the solvent for the desired flavoring or medical ingredients
- Aqueous Sol.
also known as medicated water; clear saturated aqueous solutions of volatile oils or other aromatic or volatile substances. Used mainly as flavored or perfumed vehicles.
Aromatic water (Aqueous Sol. )
are official inorganic acids and certain acids although or minor significances as the therapeutic agents but of great importance in chemical and pharmaceutical manufacturing.
Aqueous Acid (Aqueous Sol.)
aqueous sol. of acids of suitable strength usually 10% w/v except diluted Hac which is 6% w/v. They are used for internal administrator or for the manufacture of other preparations.
Diluted Acids (Aqueous Sol.)
is a liquid preparation that contains one or more soluble chemical substances dissolved in water.
Solution (Aqueous Sol. )
aqueous solutions directed against a part or into a cavity of the body as a cleansing or antiseptic agent.
Douches (Aqueous Sol. )
aka evacuation enemas. rectal injections employed to evacuate the bowel;
Enemas (Aqueous Sol. )
are aqueous solutions used for treating pharynx or the nasopharynx by forcing air
Gargles (Aqueous Sol. )
aqueous solutions which are most often used for their deodorant, refreshing or antiseptic effect
Mouthwashes (Aqueous Sol. )
are prepared from fresh ripe fruits, aqueous in character and used in making syrups employed as vehicles.
Juices (Aqueous Sol. )
are usually aqueous solutions designed to be administered to the nasal passages in drops or spray form.
Nasal Solutions (Aqueous Sol.)
aq. preparations dispensed in a container which permits the administrations of drops to the ear
Otic Solutions (Aqueous Sol. )
- Sweet or Other Viscid Aqueous Sol.
a. Syrups
b. Honey
c. Mucilages
d. Jellies
are concentrated solutions of sugar such as sucrose in water or other aq. liquids, used either as flavored syrup or medicated syrup
Syrup (Sweet)
is thick liquid preparations somewhat allied to syrup and used as a base in place of syrup
Honey (Sweet)
are thick, viscid, adhesive liquids produced by dispersing gum in water or by extracting with water the mucilaginous principles from vegetable substances
Mucilages (Sweet)
are class of gels in which the structural coherent matrix contains a high proportion of liquids.
Jellies (Sweet)
- Non-Aqueous Sol.
a. Collodion
b. Elixirs
c. Glycerin or glycerites
d. Inhalations and Inhalants
e. Liniments
f. Oleovitamins
g. Spirits
h. Toothache Drops
a liquid preparation containing pyroxillin in a mixture of ethyl ether and ethanol. applied to the skin by means of a soft brush or other suitable applicator.
Collodion (Non-Aqueous Sol.)
are clear, pleasantly flavored sweetened hydroalcoholic liquids intended for oral use, as flavors and vehicles.
Elixirs (Non-Aqueous Sol.)
are solutions or mixtures of medicinal substances on not less than 50% by weight of glycerin
Glycerin or Glycerites
drugs or solution of drugs administered by the nasal or oral respiratory route for local or systemic effect
Inhalations and Inhalants
used for the administration of inhalations
Nebulizers
drugs delivered via high power pressure carried by air current into the nasal passage
Inhalants
are solutions or mixtures of various substances in oil, alcoholic solutions of soup or emulsion, intended for external application, rubbed on affected areas
Liniments
are fish liver oils diluted with edible vegetable oil or solutions of volatile substances of the indicated vitamins or vit. concentrates on fish liver oil.
Oleovitamins
are popularly known as essences, are alcoholic or hydroalcoholic solutions of volatile substances.
Spirits
preparations used for the temporary relief of tootache
toothache drops
are a two phase system prepared by combining two immiscible liquids, one of which is uniformly dispersed through the other
Emulsions
in incorporated to prevent separation of the two phases
emulsifying agent
are a two-phase system consisting of finely divided solid dispersed in a solid, liquid, or gas. is added to ensure appropriate dispersion of the solid in the vehicle
suspensions/ suspending agent
Particle size of Solution, Colloid, Suspension:
S- less than 1nm
C- 1 to 100nm
Ss- more than 100nm
Appearance of Solution, Colloid, Suspension:
S- clear
C- cloudy
Ss- cloudy
Separation of Solution, Colloid, Suspension
S- does not separate
C- does not separate
Ss- Separate or settle
Filterability of Solution, Colloid, Suspension
S- Passes through the filter paper
C- Passes through the filter paper
Ss- Particles do not pas through the filter paper
Effect of beam of light of Solution, Colloid, Suspension
S- Light can passe through
C- Scatters Light
Ss- Light cannot passe through
Examples of of Solution, Colloid, Suspension
S- Salt Solution
C- Mayonnaise
Ss- Muddy water
either suspension made up of small inorganic particles or large organic molecules interpenetrated by a liquid
Gels-semi-solid systems
usually liquid suspension or dispersions intended for external application to the body
Lotion
aq. suspensions of insoluble inorganic drugs; they differ from gels mainly in that the suspended particles are layers
Magmas and Milks
aq. liquid preparations which contains suspended insoluble, solid substances intended for internal use
Mixture
these are solutions of the active constituents of a crude drug obtained by maceration or percolation ready for use as a medical agent or may be further process to produce solid or semisolid extracts.
Extracts
are alcoholic or hydroalcoholic sol. prepared from vegetable materials or from chemical substances
Tinctures
are liquid preparations of vegetable drugs containing alcohol as a solvent or as a preservative or both
fluidextracts
sterile prep. intended to be administered by injection under or through one or more layers of the skin or mucous membrane.
parenteral prep.
types of parenteral prep
a. Solutions ready for injections
b. Dry, soluble products ready to be combined w/ a solvent just prior to the use
c. suspensions ready for injections
d. Dry, insoluble products ready to be combined w/ a vehicle just a prior to use
e. emulsions
refers to a mixture of IVF and drugs to be administered by injection
Intravenous Admixture
sterile, large volume sol. intended to be administered by VI infusions, they contain sugar, amino acids and electrolytes
Intravenous Fluid
combination of one or more sterile products added to an IVF for administration (using aseptic technique)
IV admixture
preparation containing calories, nitrogen and other nutrients in sufficient quantities
Total Parenteral Nutrition (TPN)
intended for the eyes contain medicinal agents added to the ointment base of white petrolatum and mineral oil either as a sol. o as micronized powder
Ophthalmic Preparation Ointments
preparations designed to furnish hydrophilic coating over the characteristically hydrophilic surface of hard contact lens surface
wetting solutions
used to remove surface contaminants, lipids, proteins.
cleaning solutions
isotonic; in an acceptable pH range non reactive with lens material and sterile sol. which exhibits disinfecting activity
disinfection solution
used to store and hydrate hard lenses and to disinfect
soaking solutions
solutions intended to rewet hard lenses in situ
artificial tears
applied to skin or inserted into body orifices in liquid, semi-liquid, or solid forms
Medicated applications
a soft mass of meals, herbs, seeds, etc. usually applied hot in clothes.
Cataplasm (poultice)
concentrates of absorptive powder dispersed in petrolatum or hydrophilic petrolatum. are stiff to the point of dryness and are often used in the treatment of oozing lesions
Paste
usually describe as dusting powders.
Powder for external use
external application resembling ointment usually used as covering or protection
Dressing
viscous liquids or semi-solid emulsions of either o/w or w/o type
cream
substances intended for external application, made of such materials and of such consistency to adhere to the skin and attach to a dressing.
Plasters
solid dosage forms of various weights and shapes usually medicated for insertion into the rectum, vagina, or the urethra.
Suppositories
generally supplied as finely divided powder or as effervescent granules
oral powder
may be prepared in the form of a bulk powder generally containing soap or detergent, mild adhesive and an anticariogenic agent
Dentrifices
soluble powders intended to be dissolved in water prior to use as antiseptic or cleaning agents for a body cavity
Douche Powder
locally applied non-toxic preparation that are intended to have no systemic action.
Dusting powders
finely divided powders introduced into the body cavities such as the ears, nose, throat, tooth sockets and vagina with the use of an insufflator(powder blower)
Insufflations
dilutions of potent powdered drugs prepared by intimately mixing with a suitable diluent in 1:10 dilutions
Triturations
solid dosage forms containing drug substances
tablets
solid dosage forms in which the drug substance is enclosed in either a hard or soft container
capsules
small, round, solid dosage forms containing medicinal agents and intended for oral administration
pills
small, sterile cylinders about 3.2mm in diameter by 8mm in length, formed by compression from medicated masses
pellets
used both orally and topically, contain therapeutically active ingredients dissolves, suspended, or emulsified in a propellant or in a mixture of solvent and propellant.
aerosols
used for the symptomatic tx of asthma, migraine headache
oral aerosols
used to treat a multitude of dermatological manifestations
topical aerosols
used in medicine for therapeutic and diagnostic purposes
radioisotopes
suspension of attenuated(live) or inactivated(killed) microorganism of fraction thereof administered to induce immunity and thus prevent infectious disease
vaccine
A modified antigen from an infectious organism used as a vaccine.
toxoid
a solution containing antibodies from the pooled plasma of not less than 1000 normal individuals
1.1 immunoglobulin
a special preparation obtained from human donor pools selective for high antibody titer against a specific disease
hyperimmune serum
a solution antibodies derived form the serum of animals immunized with specific toxins (toxoid)
antitoxin
a solution of antibodies derived from the serum of animals immunized with specific viral vaccines
antiviral serum
a preparation of antibodies derived from the serum of animals immunized with specific venom used to neutralize the venom produced by the specific organism
antivenin