Introduction to Hematologic Malignancies II

Question 1

List the basic functional categories for hematologic malignancies, as outlined in the notes, and contrast the basic expected findings in the blood and marrow for these categories: acute leukemias

Answer 1

usually due to the rapid accumulation of (usually) immature cells in the marrow. These immature cells often replace many of the normal marrow cells, resulting in cytopenias (thrombocytopenia, anemia, neutropenia, etc.) Often, but not always, the immature cell is the generic-appearing blast.

Question 2

List the basic functional categories for hematologic malignancies, as outlined in the notes, and contrast the basic expected findings in the blood and marrow for these categories: myelodysplastic syndrome (MDS)

Answer 2

clonal population derived from a neoplastic hematopoietic stem cell takes over the marrow, and is not capable of making normal blood cells in one or more lineages (dysplasia). This disease is categorized in most cases by falling peripheral blood cell counts.

Question 3

List the basic functional categories for hematologic malignancies, as outlined in the notes, and contrast the basic expected findings in the blood and marrow for these categories: Myeloproliferative neoplasms (MPNs)

Answer 3

clonal proliferations of the marrow where the clone makes normal functioning blood cells, usually in multiple lineages, but makes too many of them in one or more lineages.

Question 4

List the basic functional categories for hematologic malignancies, as outlined in the notes, and contrast the basic expected findings in the blood and marrow for these categories: Classical Hodgkin Lymphoma (CHL)

Answer 4

HRS cells derive from B cells

Question 5

List the basic functional categories for hematologic malignancies, as outlined in the notes, and contrast the basic expected findings in the blood and marrow for these categories: Non-Hodgkin Lymphoma

Answer 5

any malignancy derived from mature B cells (excluding CHL or plasma cell neoplasms), T cells, or NK cells. The large majority are derived from B cells

Question 6

List the basic functional categories for hematologic malignancies, as outlined in the notes, and contrast the basic expected findings in the blood and marrow for these categories: Plasma cell neoplasms

Answer 6

apparently this category is self-explanatory