Introduction to Amino Acids Flashcards

1
Q

What are proteins?

A

Proteins are macromolecules made up of a chain of amino acids joined by peptide bonds

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2
Q

How are proteins made?

A

Made by the transcription of DNA to RNA and then translation of RNA to protein

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3
Q

How are dietary proteins broken down?

A

They are broken down by proteases (pepsin) and hydrochloric acid in the stomach

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4
Q

Give three uses of amino acids.

A

Production of hormones

Production of enzymes

Production of proteins

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5
Q

What are amino acids?

A

The building blocks of proteins

An amine group
A carboxylic acid group
A variable group (R)
And a hydrogen all bonded to a single carbon

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6
Q

What is an amine group?

A

NH2

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7
Q

What is a carboxylic acid group?

A

COOH (where C=O and C-OH)

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8
Q

How can the bonds between amino acids be broken?

A

Broken via acid or enzyme action

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9
Q

How would you describe the shape of amino acids?

A

Tetrahedral structures

Carbon at the centre with four bonds stretching out at the furthest angle from each other

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10
Q

In general what are the two different ways amino acids can be configured?

A

L amino acids (Left-handed)

D amino acids (Right-handed)

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11
Q

In relation to its configuration, how does glycine compare to all the other amino acids?

A

Glycine is the only amino acid that is not a stereoisomer

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12
Q

What is a steriosomer?

A

A molecule that are mirror images of their structure

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13
Q

Explain what is meant by L and D amino acids.

A

L and D refers to whether or not the configuration of an amino acid is the left mirror image or the right mirror image of an amino acid

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14
Q

In general, where are L amino acids made?

A

They are manufactured in cells

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15
Q

What are L amino acids generally used for?

A

The are generally incorporated into proteins

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16
Q

Where are D amino acids generally found?

A

In the cell wall of bacteria

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17
Q

Define essential amino acids.

2

A

Amino acids that cannot be produced by the body

They must be acquired via dietary or supplementary means

18
Q

Define conditionally non-essential amino acids.

A

Amino acids produced by the body but in lower amounts and outside supplementation may be required e.g. in case of pregnancy

19
Q

Define non-essential amino acids.

A

Amino acids that can be produced by the body and therefore not required via dietary or supplementary means

20
Q

List some of the essential amino acids.

4

A

Leucine
Isoleucine
Phenylalanine
Tryptophan

21
Q

List the four non-essential amino acids.

A

Alanine
Asparatate
Cysteine
Glutamate

22
Q

List some conditionally non-essential amino acids.

A

Asparagine
Glycine
Glutamine
Tyrosine

23
Q

What are the three ways to classify amino acids?

A

On the basis of R group

On the basis of nutrition

On the basis of catabolism

24
Q

How can amino acids be classified according to their R group?
(4)

A

Hydrophobic

Hydrophilic

Acidic

Basic

25
Q

How can amino acids be classified on the basis of nutrition?
(3)

A

Essential

Conditionally non essential

Non essential

26
Q

How can amino acids be classified on the basis of catabolism?
(3)

A

Glucogenic

Ketogenic

Both Glucogenic and Ketogenic

27
Q

Where are most hydrophobic amino acids found?

A

Most are found buried within the core of a protein structure

28
Q

Where are most hydrophilic amino acids found?

A

Most are found on the outside of a protein structure

29
Q

What can hydrophobic amino acids also be called?

A

Polar amino acids

30
Q

What can hydrophilic amino acids also be called?

A

Non polar amino acids

31
Q

Give four examples of hydrophobic amino acids.

A

Phenylalanine
Tryptophan
Leucine
Isoleucine

32
Q

Give four examples of hydrophilic amino acids/

A

Asparagine
Glutamine
Tyrosine
Cysteine

33
Q

How do you know if an amino acid is hydrophilic or hydrophobic?

A

Hydrophilic amino acids will have an electronegative atom such as O, S or N as part of their variable group

Hydrophobic amino acids will have only carbons and hydrogens as part of their variable group

34
Q

List two acidic amino acids.

A

Aspartic acid

Glutamic acid

35
Q

How do you know if an amino acid is acidic?

A

The presence of O-

COO-

36
Q

List three basic amino acids.

A

Lysine
Arginine
Histidine

37
Q

How do you know if an amino acid is basic?

A

The presence of a nitrogen, hydrogen molecule with an overall positive charge

38
Q

What are glucogenic amino acids?

A

Amino acids that can be converted into glucose

39
Q

What are ketogenic amino acids?

A

Amino acids that can be degraded directly into acetyl-CoA

40
Q

List the only two ketogenic amino acids.

A

Leucine

Lysine