Introduction to Absorption, Distribution, Metabolism, and Excretion

Question 1

Identify what percent of drugs currently fail in clinical trials due to problems with ADME

Answer 1

LESS THAN 10%

Question 2

Identify the primary routes of administration

Answer 2

• Ingestion
• Inhalation
• Dermal
• Parenteral
  Intravenous
  Subcutaneous
  Intramuscular
  Intraperitoneal

Question 3

Describe the four potential consequences of drug metabolism (biotransformation) as it relates to pharmacologic activity

Answer 3

Active Drug to Inactive Metabolite
Active Drug to Active Metabolite
Inactive Drug to Active Metabolite
Active Drug to Reactive Metabolite

Question 4

Define disposition

Answer 4

The fate of a drug after it has entered the systemic circulation

Question 5

Define pharmacokinetics

Answer 5

The study of the absorption, distribution, biotransformation, and elimination of xenobiotics
(What the body does to the drug)

Question 6

Define pharmacodynamics

Answer 6

The study of the molecular, biochemical, and physiological effects of xenobiotics and their mechanisms of actions
(What the drug does to the body)