Introduction

Question 1

What is the importance of protein structure

Answer 1

1. Proteins are the workers- performing a variety of biological tasks
2. Each protein has a particular 3D structure that brings into close proximity residues that are far apart in the amino acid sequence
3. Each protein adopts a particular folding pattern that determines its function
4. During normal cells life, most newly synthesised proteins fold spontaneously

Question 2

What are the 4 levels of protein structure

Answer 2

1. Primary structure
2. Secondary structure
3. Tertiary structure
4. Quaternary structure

Question 3

What is the basics of the primary structure

Answer 3

1. Sequence of amino acids

2. Amino to carbonyl end

Question 4

What are the basics of the secondary structure

Answer 4

1. Local folding arrangement
2. Relationship of an amino acid to its neighbours in the chain
3. Beta pleated sheet and alpha helix

Question 5

What are the basics of the tertiary structure

Answer 5

1. Complete 3D structure of the protein chain

Question 6

What are the basics of the quaternary structure

Answer 6

1. Spatial arrangement of multiple chains found in some proteins

Question 7

What can protein structure tell you

Answer 7

1. Understand biological processes at basic level
2. Understand disease at an atomic level
3. Help develop new drugs
4. Engineer new and improved proteins for various application

Question 8

What is the definition of genome

Answer 8

1. Genome- Entire chromosomal genetic material of an organism

Question 9

what is the definition of genomics

Answer 9

1. Genomics- comprehensive study of whole sets of genes and their interactions

Question 10

What is the definition of proteome

Answer 10

1. Proteome- full complement of proteins produced by the genome

Question 11

What is the definition of proteomics

Answer 11

1. Proteomics- study of full set of proteins encoded by the genome

Question 12

What is a structural genomics

Answer 12

1. Molecule study - structural genomics

Question 13

What is a structural proteomics

Answer 13

1. Pathway study- structural proteomics- interactions

Question 14

What is structural systems biology

Answer 14

1. Activity of proteins

Question 15

What techniques other than microscopes are needed to study proteins

Answer 15

1. X-ray crystallography
2. Nuclear magnetic resonance
3. Cryo-electron microscopy

Question 16

What is the protein data bank

Answer 16

1. protein structures are deposited

2. currently 169000 entries