Introduction Flashcards
Dog order, family, genus, species, and subspecies.
Order Carnivora, Family Canidae. Canis lupus familiaris
Random sourced dogs used in research are typically what breeds for what purposes?
Mongrels or larger dog breeds for surgical research and/or training.
What are beagles commonly used for in research?
Pharmacology or toxicology. Dental and periodontal disease and surgery, orthopedic surgery, canine infectious disease, ophthalmology.
Why are most large-sized dogs used in research? As models for what?
Suitability for surgical procedures. Anesthetic protocols well established, organs an appropriate size for trials of pediatric surgical procedures. Cardiovascular, orthopedic, and transplantation research.
What dog breed is a model of cyclic hematopoiesis? What characterizes this model? What is this model specifically used to study?
Gray collies at University of Washington, Seattle. Periodic fluctuations of the cellular components of the blood, most notably peripheral neutrophils. Study basic regulatory mechanisms involved with hematopoiesis, as well as possible treatments.
What dog breed is a model for Duchenne muscular dystrophy? How is the disease similar to that in humans?
Golden retrievers. Caused by absence of muscle protein dystrophin, inherited in an X-linked recessive manner, as in humans. Also show similar clinical signs, including debilitating hind limb contracture.
What diseases are studied in Doberman pinschers? Bedlington terriers? Several breeds of dogs?
Hereditary canine spinal muscle atrophy and narcolepsy. Cooper storage diseases, such as Wilson’s disease. Spontaneous diabetes mellitus and hypothyroidism in several breeds of dogs.
Why has dog use in research declined?
Decreased availability, local restrictive regulations, conversion to other animal models, increased cost, and shift in scientific interest from pathophysiology to molecular biology and genetics
What preventative care do purpose-bred dogs receive?
Rabies, DAPP + Lepto vaccine, Bordetella, Treated prophylactically for intestinal helminths and ectoparasites, probably given a heartworm preventative.
What are conditioned dogs?
Random-source dogs that have been treated and vaccinated in preparation for use in research.
How are nonconditioned random-source dogs useful?
In limited number of research studies. Nonsurvival surgical training preparations and tissue/organ harvest.
What policy did the NIH issue in 2013? When did it take effect? What did it mandate?
Notice Regarding NIH plan to transition from use of USDA Class B dogs to other legal sources. Fiscal year 2015. Prohibits procurement of dogs from Class B dealers using NIH grant funds. Dogs must be obtained from Class A vendors, privately owned colonies, or client-owned animals.
As per the AWA, how is dog space calculated? How is it calculated per the Guide?
AWA: Body length
Buide: Body weigth
