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Introduction Flashcards

1
Q

DNA viruses

A

HHAPPPPy
1. Herpes
2. Hepadna
3. Adeno
4. Pox
5. Parvo
6. Papilloma
7. Polyoma

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2
Q

Enveloped DNA viruses

A

Pox, Herpes, Hepadna

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3
Q

Properties of DNA viruses:

Biggest

A

Poxviridae

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4
Q

Properties of DNA viruses:

Only virus that replicate in the cytoplasm

A

Poxviridae

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5
Q

Properties of DNA viruses:

Brick-shaped enveloped (non-icosanedral)

A

Poxviridae

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6
Q

Properties of DNA viruses:

Heaviest

A

Herpesviridae

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7
Q

Properties of DNA viruses:

Lightest

A

Parvoviridae

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8
Q

All DNA viruses are enveloped, except

A

PAPP smear
(Parvo-, Adeno-, Papilloma-, Polyomavirus)

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9
Q

All DNA viruses are dsDNA except

A

parvovirus

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10
Q

All DNA viruses are linear except

A

PoHPa (Polyoma-, Hepadna-, Papillomavirus)

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11
Q

All DNA viruses have icosahedral capsids except

A

poxvirus

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12
Q

All DNA viruses replicate in the nucleus except

A

poxvirus

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13
Q

RNA respiratory viruses

A
  1. Paramyxoviridae
  2. Orthomyxoviridae
  3. Coronaviridae
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14
Q

All RNA viruses are enveloped except

A

CPR (+H ) or PRC examination

Calci-, Picorna-, Reovirus+Herpesvirus

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15
Q

All RNA viruses are ssRNA except

A

Reovirus

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16
Q

All RNA viruses are icosahedral capsids, except for few helical viruses

A

A HELYX

A - Arenavirus
H – Rhabdovirus
E – Emperor’s wear crown “corona”-virus
L – DeLtavirus, FiLovirus
Y – BunYavirus
X – orthomyXo- and paramyxovirus

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17
Q

All RNA viruses are linear except 3 circular ones:

A

• Arenavirus – arenas are round
• Bunyavirus – bunions are round
• Deltavirus – the Greek letter “6” round

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18
Q

All RNA viruses have replicate in the cytoplasm except:

A

Orthomyxo and Retrovirus

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19
Q

virus particle consist of a nucleic acid genome (DNA or RNA)

A

Virion

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20
Q

interaction of a virion with a specific receptor site on the surface of a cell.

A

Attachment

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21
Q

Examples of Viral attachments:

Rhinovirus

A

VP1-VP2-VP3 complex

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22
Q

Examples of Viral attachments:

Adenovirus

A

Fiber protein

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23
Q

Examples of Viral attachments:

Influenza A virus

A

HAgp

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24
Q

Examples of Viral attachments:

Measles Virus

25
Q

Examples of Viral attachments:

HIV

26
Q

Examples of Viral receptors:

EBV

A

C3d Complement Receptor (CR2,CD21)
Tc: B cell

27
Q

Examples of Viral receptors:

HIV

A

CD4
Tc: T Helper Cells

28
Q

Examples of Viral receptors:

Influenza A virus

A

Sialic acid
Tc: Epithelial Cells

29
Q

Examples of Viral receptors:

B19 Parvovirus

A

Erythrocyte P antigen
Tc: Erythroid precursor

30
Q

process where virus attaches to the wall of a cell and is absorbed into the cell through phagocytosis.

A

Viropexis (Picorna-, Papilloma-, Polyomavirus)

31
Q

normal process used by cell for the uptake of receptor-bound molecules

A

Endocytosis (hormones, LDL, and transferrin)

32
Q

is the physical separation of the viral nucleic acid from the outer structural components of the virion so that it can function.

33
Q

assembled as procapsids to be filled w/ genome (picornavirus) or assembled around the genome

A

Capsid viruses

34
Q

delivered to cell membrane by vesicular transport (Budding).

A

Enveloped virus

35
Q

Virus can be released after lysis of the cell, by ________, or by ______ from the plasma membrane.

A

exocytosis, budding

36
Q

buds into the ER and Golgi membrane.

A

Flavi-, Corona-, bunyavirus

37
Q

assemble in nucleus and buds in and out of the adjacent ER

38
Q

Properties of DNA viruses:

Requires cell undergoing DNA synthesis to replicate

A

Parvovirus

39
Q

Properties of DNA viruses:

Stimulates cell growth and DNA synthesis

A

Papillomavirus and Polyomavirus

40
Q

Properties of DNA viruses:

Stimulates cell growth, cell makes RNA intermediate, encodes a reverse transcriptase

A

Hepadnavirus

41
Q

Properties of DNA viruses:

Stimulates cellular DNA synthesis and encodes its own polymerase

A

Adenovirus

42
Q

Properties of DNA viruses:

Stimulates cell growth, encodes its own polymerase and enzymes to provide deoxyribonucleotides for DNA synthesis, establishes latent infection in host

A

Herpesvirus

43
Q

Properties of DNA viruses:

Encodes its own polymerases and enzymes to provide deoxyribonucleotides for DNA synthesis, replication machinery, and transcription machinery in the cytoplasm

44
Q

(+) RNA genome resembles mRNA and is translated into a polyprotein, which is proteolyzed. A (-) RNA template is used for replication.

A

Picornaviruses, Togaviruses, Flaviviruses, Caliciviruses, and Coronaviruses

45
Q

(-) RNA genome is a template for individual mRNAs, but full-length (+)
RNA template is required for replication.

A

Orthomyxoviruses, Paramyxoviruses, Rhabdoviruses, Filoviruses, and Bunyaviruses

46
Q

(+/-) Segmented RNA genome is a template for mRNA (+RNA). (+) RNA may also be encapsidated to generate the (+/-) RNA and then more mRNA.

A

Reoviruses

47
Q

(+) RNA genome is converted into DNA, which is integrated into the host chromatin and transcribed as a cellular gene

A

Retroviruses

48
Q

Cytopathogenesis

Failed infection

A

abortive infection

49
Q

Cytopathogenesis

Cell death

A

lytic infection

50
Q

Cytopathogenesis

Replication without cell death

A

persistent infection

51
Q

Cytopathogenesis

Presence of virus without virus production but with potential for reactivation

A

latent-recurrent infection

52
Q

Inclusion Bodies

Negri bodies (intracytoplasmic)

53
Q

Inclusion Bodies

Intranuclear basophilic (Owl’s eye)

A

Cytomegalovirus (enlarged cells), adenoviruses

54
Q

Inclusion Bodies

Cowdry type A (intranuclear)

A

HSV, subacute sclerosing panencephalitis (measles) virus

55
Q

Inclusion Bodies

Intracytoplasmic acidophilic

A

Poxviruses

56
Q

Inclusion Bodies

Perinuclear cytoplasmic acidophilic

A

Reoviruses

57
Q

Tissue culture:
Primary

A

monkey kidney cells (influenza virus)

58
Q

Tissue culture:

Diploid cell line

A

fibroblastic cells (HSV, VZV, CMV)

59
Q

Tissue culture:

Tumor or immortalized cell line

A

HeLa cells (RSV, HSV)

Virology (5 decks)

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