Introduction Flashcards
defined molecular biology as the study of dna
james watson
head of the natural science division of the rockfeller foundation
warren weaver
first to use the term molecular biology
warren weaver
deals with molecular techniques for handling and analysis of nucleic acids
diagnostic molecular biology
discovered dna and extracted nuclein
john friedrich miescher
first to demonstrate bacterial transformation
frederick griffith
type s
virulent
type r
non virulent
implicated that DNA is responsible for bacterial transformation
avery, macleod, mccarty
enzyme that digest proteins
proteases
enzymes that breaks apart RNA
ribonucleases
enzymes that act on DNA
DNases
took the photo 51
rosalind franklin & raymond gosling
studies of DNA’s structure through X-ray diffraction
(X-ray crystallography)
helped confirmed that DNA is the genetic material by performing experiments
alfred hershey and martha chase
performed chromatographic methods about adenine, thymine, guanine, cytosine
erwin chargaff
adenine is equal to
thymine
guanine is equal to
cytosine
published in nature, the first correct model of the DNA molecule
james watson and francis crick
utilized franklin’s “photo 51”
james watson and francis crick
they performed the first known successful DNA recombinant experiment
herbert boyer and stanley norman cohen
seperately developed techniques for rapid DNA sequencing
walter gilbert and frederick sanger
invented the pcr technique
kary mullis
presented the zinc finger nucleases
nikola panayot pavletich and carl pabo
first to generate the mammalian clone, dolly the sheep
sir ian wilmut
a roundworm who became the first multicellular organism to have its entire genome decoded
caenorhabditis elegans
first crop to have its entire genum decoded
rice
this project completely mapped and identified all of the genes of the human genome
human genome project
enzymes that can be engineered to cut specific dna sequences
talens
meaning of talens
transcription activator-like effector nucleases
utilized for genome editing purposes
crispr-cas9
meaning of crispr
clustered regularly interspaced short palindromic repeats
refers to the analysis of nucleic acids and proteins for diagnosis
molecular pathology
PREDICT disease progression
prognosis
DETECT normal and disease states
diagnosis
identifying the gene expression pattern
redefinition of diseases
molecular biology enabled clinicians to identify genes that have the potential of causing cancer
detection of cancer
molecular techniques have enabled the detection of pathogens
detection of infectious diseases
genetic screeing for the presence of proteins involved in drug metabolism
treatment of diseases
studies how drug responses occur concerning an individual’s genome
pharmacogenomics and personalized medicine
diagnostic molecular techniques have been of great assistance for predicting the manifestation of genetic diseases
diagnostic of genetic diseases