Introduction

Question 1

Refers to the number of patients w/ the condition per 1000 of a defined population at any point in time.

Answer 1

Prevalence

Question 2

Refers to the number of new patients w/ the condition per 1000 of a defined population in a defined time period.

Answer 2

Incidence

Question 3

What is the prevalence of single-gene disorder?

Answer 3

20 – 30 per 1000

Question 4

Other factors that can also play a role in the prevalence of individual single-gene disorder are ____ & _____.

Answer 4

genetic drift (in small populations)

population migration (where the incoming migrants possess different allele frequencies)

Question 4

The population prevalence of individual single - gene disorders may be influenced by three main factors:

Answer 4

selection;
a founder effect;
any alteration to the mutation rate.