Introduction

Question 1

It is to formulate, manufacture, use, dispense, determine, stability, effectivity and safety or a drug formulation

Answer 1

Pharmaceutics

Question 2

Study of factors that influence BIOAVAILABILITY of a drug.

Answer 2

Biopharmaceutics

Question 3

Use of biopharmaceutics

Answer 3

For OPTIMUM PHARMACOLOGIC or THERAPEUTIC ACTIVITY of drug products.

Question 4

RATE or EXTENT of systemic absorption of the active drug.

Answer 4

Bioavailability

Question 5

Determines the FATE OF SUBSTANCES administered in a living organism

Answer 5

Pharmacokinetics

Question 6

What does Pharmacokinetics ask

Answer 6

What the body does to the drug?

Question 7

It studies the action of drugs in TARGET ORGANS

Answer 7

Pharmacodynamics

Question 8

Pharmacodynamics include

Answer 8

Mechanisms of drug action
Relationship between drug concentration and effect

Question 9

How GENETIC VARIATIONS affect drug response

Answer 9

Pharmacogenetics

Question 10

Study of the DIFFERENT FORMULATIONS with comparable bioavailability when studied at similar conditions.

Answer 10

Bioequivalence

Question 11

Adjustable factors of Pharmacokinetics include

Answer 11

Dose
Dosage form
Route of administration

Question 12

Drug concentration vs. time

Answer 12

Body’s response to drug exposure

Question 13

Pharmacodynamics rely on

Answer 13

Variabilities

Question 14

It is the DRUG TOWARDS TIME

Answer 14

Area under the curve

Question 15

Quantitative basis of drug therapy

Answer 15

Amount of dose administered (How much)
Frequency of administration (How often)
Duration of treatment (For how long)

Question 16

What level produces SUFFERING?

Answer 16

Toxic level

Question 17

A level where the DRUG TAKE EFFECT in a certain time or concentration

Answer 17

Therapeutic window or range

Question 18

The level where the drug did NOT PROVIDE therapeutic effects

Answer 18

Subtherapeutic level/ineffective therapy

Question 19

APPLICATION of pharmacokinetic methods to drug therapy in PATIENT CARE

Answer 19

Clinical Pharmacokinetics

Question 20

Clinical Pharmacokinetics involved MULTI-DISCIPLINARY APPROACH to individually optimized dosing strategies based on

Answer 20

Patients diseased state
Patient-specific considerations

Question 21

ORGANS that have a VITAL ROLE in Pharmacokinetics

Answer 21

Liver
Kidney

Question 22

What race makes ARBs NON EFFECTIVE

Answer 22

African-American

Question 23

Application of Clinical Pharmacokinetics

Answer 23

Therapeutic drug monitoring

Question 24

What does TDM monitors

Answer 24

Plasma drug concentration
Pharmacodynamic endpoints

Question 25

It is the CONCENTRATION of drug within the BLOOD

Answer 25

Plasma drug concentration

Question 26

TDM is usually CONDUCTED for

Answer 26

Very potent drugs/narrow therapeutic range

Question 27

It is OUT of the MAXIMAL DOSE

Answer 27

Potent

Question 28

Example of potent drugs

Answer 28

Digoxin-Cardiac glycoside

Question 29

RELEASE of the active ingredient

Answer 29

Liberation

Question 30

In liberation, the RATE of drug release from a dosage form would highly DEPEND on

Answer 30

Dosage form

Question 31

When the amount of active ingredient reaches the SYSTEMIC CIRCULATION

Answer 31

Absorption

Question 32

TRANSFER of active ingredients from the site of absorption to the site of action

Answer 32

Distribution

Question 33

Use of receptors

Answer 33

For the drug to take effect

Question 34

CHEMICAL TRANSFORMATION of a drug to it's metabolite to be ready for excretion

Answer 34

Metabolism

Question 35

REMOVAL of metabolites

Answer 35

Excretion

Question 36

Most drugs are excreted by the __________ in the form of __________

Answer 36

Kidneys Urine

Question 37

Other drugs maybe removed from the body through

Answer 37

Sweat Saliva Exhaled air Feces

Question 38

EFFECT brought about by the drug to the patient

Answer 38

Response

Question 39

Factors of a drug response

Answer 39

Drug formulation (Pharmaceutics) Drugs inert activity (Pharmacology) Genetic makeup (Pharmacogenetics)

Question 40

Biopharmaceutics is a field of science that examines the INTERRELATIONSHIP of the

Answer 40

Physicochemical property Dosage form Route of administration

Question 41

What clinical testing involves the STABILITY of the drug, toxicity effects and does not exceed therapeutic window.

Answer 41

Animal testing

Question 42

What clinical testing focuses on the SAFETY, have SMALLER and SIMILAR characteristics of respondents. Upon the increase or decrease of dose would provide toxic effects.

Answer 42

Phase 1

Question 43

What clinical trial focuses on SAFETY and EFFICACY. LARGER population NO STAGING

Answer 43

Phase 2

Question 44

Clinical trial with diversified COMORBIDITIES

Answer 44

Phase 3

Question 45

Clinical trial where drugs are already RELEASED in the MARKET Monitor, efficacy, toxicity, ADR Post - marketing surveillance

Answer 45

Phase 4