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Biopharmaceutics > Introduction > Flashcards

Introduction Flashcards

1
Q

It is to formulate, manufacture, use, dispense, determine, stability, effectivity and safety or a drug formulation

A

Pharmaceutics

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2
Q

Study of factors that influence BIOAVAILABILITY of a drug.

A

Biopharmaceutics

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3
Q

Use of biopharmaceutics

A

For OPTIMUM PHARMACOLOGIC or THERAPEUTIC ACTIVITY of drug products.

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4
Q

RATE or EXTENT of systemic absorption of the active drug.

A

Bioavailability

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5
Q

Determines the FATE OF SUBSTANCES administered in a living organism

A

Pharmacokinetics

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6
Q

What does Pharmacokinetics ask

A

What the body does to the drug?

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7
Q

It studies the action of drugs in TARGET ORGANS

A

Pharmacodynamics

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8
Q

Pharmacodynamics include

A

Mechanisms of drug action
Relationship between drug concentration and effect

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9
Q

How GENETIC VARIATIONS affect drug response

A

Pharmacogenetics

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10
Q

Study of the DIFFERENT FORMULATIONS with comparable bioavailability when studied at similar conditions.

A

Bioequivalence

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11
Q

Adjustable factors of Pharmacokinetics include

A

Dose
Dosage form
Route of administration

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12
Q

Drug concentration vs. time

A

Body’s response to drug exposure

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13
Q

Pharmacodynamics rely on

A

Variabilities

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14
Q

It is the DRUG TOWARDS TIME

A

Area under the curve

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15
Q

Quantitative basis of drug therapy

A

Amount of dose administered (How much)
Frequency of administration (How often)
Duration of treatment (For how long)

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16
Q

What level produces SUFFERING?

A

Toxic level

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17
Q

A level where the DRUG TAKE EFFECT in a certain time or concentration

A

Therapeutic window or range

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18
Q

The level where the drug did NOT PROVIDE therapeutic effects

A

Subtherapeutic level/ineffective therapy

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19
Q

APPLICATION of pharmacokinetic methods to drug therapy in PATIENT CARE

A

Clinical Pharmacokinetics

20
Q

Clinical Pharmacokinetics involved MULTI-DISCIPLINARY APPROACH to individually optimized dosing strategies based on

A

Patients diseased state
Patient-specific considerations

21
Q

ORGANS that have a VITAL ROLE in Pharmacokinetics

A

Liver
Kidney

22
Q

What race makes ARBs NON EFFECTIVE

A

African-American

23
Q

Application of Clinical Pharmacokinetics

A

Therapeutic drug monitoring

24
Q

What does TDM monitors

A

Plasma drug concentration
Pharmacodynamic endpoints

25
Q

It is the CONCENTRATION of drug within the BLOOD

A

Plasma drug concentration

26
Q

TDM is usually CONDUCTED for

A

Very potent drugs/narrow therapeutic range

27
Q

It is OUT of the MAXIMAL DOSE

A

Potent

28
Q

Example of potent drugs

A

Digoxin-Cardiac glycoside

29
Q

RELEASE of the active ingredient

A

Liberation

30
Q

In liberation, the RATE of drug release from a dosage form would highly DEPEND on

A

Dosage form

31
Q

When the amount of active ingredient reaches the SYSTEMIC CIRCULATION

A

Absorption

32
Q

TRANSFER of active ingredients from the site of absorption to the site of action

A

Distribution

33
Q

Use of receptors

A

For the drug to take effect

34
Q

CHEMICAL TRANSFORMATION of a drug to it’s metabolite to be ready for excretion

A

Metabolism

35
Q

REMOVAL of metabolites

A

Excretion

36
Q

Most drugs are excreted by the __________ in the form of __________

A

Kidneys
Urine

37
Q

Other drugs maybe removed from the body through

A

Sweat
Saliva
Exhaled air
Feces

38
Q

EFFECT brought about by the drug to the patient

A

Response

39
Q

Factors of a drug response

A

Drug formulation (Pharmaceutics)
Drugs inert activity (Pharmacology)
Genetic makeup (Pharmacogenetics)

40
Q

Biopharmaceutics is a field of science that examines the INTERRELATIONSHIP of the

A

Physicochemical property
Dosage form
Route of administration

41
Q

What clinical testing involves the STABILITY of the drug, toxicity effects and does not exceed therapeutic window.

A

Animal testing

42
Q

What clinical testing focuses on the SAFETY, have SMALLER and SIMILAR characteristics of respondents.
Upon the increase or decrease of dose would provide toxic effects.

A

Phase 1

43
Q

What clinical trial focuses on SAFETY and EFFICACY.
LARGER population
NO STAGING

A

Phase 2

44
Q

Clinical trial with diversified COMORBIDITIES

A

Phase 3

45
Q

Clinical trial where drugs are already RELEASED in the MARKET
Monitor, efficacy, toxicity, ADR
Post - marketing surveillance

A

Phase 4

Biopharmaceutics (3 decks)

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