Intro to WBC Neoplasms

Question 1

Core biopsy of bone marrow allows you to see what?

Answer 1

Check metastasis, fibrosis and general architecture

Question 2

Immature cell marker (1)

Answer 2

CD34

Question 3

Myeloid cell markers (3)

Answer 3

CD13, CD33, MPO

Question 4

B Cell Markers (3)

Answer 4

CD19, CD20, kappa and lambda chains

Question 5

T Cell markers (5)

Answer 5

CDIa, CD3, CD4/8, CD7, CD5

Question 6

CD45

Answer 6

leukocyte common antigen

Question 7

CD10

Answer 7

marker sometimes present on myeloid cells or B lymphoblasts

Question 8

TdT

Answer 8

Present on immature lymphoid cells

Question 9

CD15, CD30

Answer 9

markers of Hodgkin’s lymphoma

Question 10

15, 17 translocation is associated with what?

Answer 10

Acute Myeloid Leukemia

Acute Promyelocytic Leukemia

Question 11

9, 22 translocation is associated with what?

Answer 11

Chronic Myelogenous Leukemia

Question 12

Mutations in these 3 genes that regulate hematopoiesis can give a survival advantage to mutated cells

Answer 12

FLT3, NPMI, JAK2

Question 13

14, 18 translocation is associated with what?

Answer 13

Follicular Lymphoma

Question 14

8, 14 translocation is associated with what?

Answer 14

Burkitt Lymphoma

Question 15

11, 14 translocation is associated with what?

Answer 15

Mantle Cell Lymphoma

Question 16

Fanconi anemia increases the risk for what?

Answer 16

Acute Leukemia

Question 17

Down Syndrome and Neurofibromatosis 1 increase the risk for what?

Answer 17

Childhood leukemias

Question 18

HTLV-1 virus is associated with what?

Answer 18

Adult T Cell Leukemia/ lymphoma

Question 19

HHV8 virus is associated with what?

Answer 19

Pleural Effusion Lymphoma

Question 20

Lymph node enlargement is

Answer 20

Lymphadenopathy

Question 21

Lymph node inflammation (typically tender) is

Answer 21

Lymphadenitis

Question 22

5 causes of lymphadenopathy

Answer 22

Infection, autoimmune disease, iatrogenic, malignancy and other factors (ex- sarcoidosis, dermatopathic lymphadenopathy)

Question 23

Aspirate bone marrow cells allow you to see what?

Answer 23

Individual cell morphology and number

Question 24

Features of Follicular Hyperplasia (4)

Answer 24

1. Mantle Zone polarization
2. Normal Bcl2 staining (mantle stains)
3. Large germinal center
4. Presence of Tingable body macrophages

Question 25

Features of Paracortical Hyperplasia (3)

Answer 25

1. Paracortical (T cell area) expansion 2. Histiocytes (macrophages) are present in sinuses 3. Possible concurrent follicular hyperplasia

Question 26

Acute Nonspecific Lymphadenitis is characterized by

Answer 26

Enlarged, red, tender soft nodes

Question 27

What is the usual cause of acute nonspecific lymphadenitis and what demographic is typically involved

Answer 27

Kids- drainage infections Teeth, tonsils --> cervical Extremities, groin --> axillary/inguinal nodes Appedicitis, yersinia --> mesenteric

Question 28

What is characteristic of Chronic Nonspecific Lymphadenitis and what is the cause?

Answer 28

- Non-tender nodes presenting with any of the histological pattens - Caused by chronic immunologic stimulation

Question 29

Lymphomas typically present with

Answer 29

non-tender adenopathy (66%); 33% present with extranodal tissue involvement

Question 30

Leukemia symptoms

Answer 30

Symptoms of Bone Marrow Failure: poor clotting, bruising, petechia, anemia, more infections

Question 31

What is a plasma cell neoplasm?

Answer 31

Type of Lymphoid Neoplasm that involves terminally differentiated B cells that results in bony destruction (lytic lesions) and involved bone marrow

Question 32

General Symptoms of Lymphoma

Answer 32

lumps/bumps present for more than 2 months, hard lymph nodes, weight loss

Question 33

Differentiating Hodgkin and Non Hodgkin Lymphoma

Answer 33

HL- spreads in a systemic fashion | NHL- at diagnosis is more disseminated on a molecular level

Question 34

Diagnostic features that suggest lymphoid neoplasms (4)

Answer 34

1. Loss of immune vigilance --> more infections 2. Loss of immune tolerance --> autoimmunity 3. Adenopathy that cannot be explained 4. B Symptoms (fever, sweats, weight loss)