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Disease and Therapeutics 1 > Intro to WBC Neoplasms > Flashcards

Intro to WBC Neoplasms Flashcards

1
Q

Core biopsy of bone marrow allows you to see what?

A

Check metastasis, fibrosis and general architecture

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2
Q

Immature cell marker (1)

A

CD34

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3
Q

Myeloid cell markers (3)

A

CD13, CD33, MPO

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4
Q

B Cell Markers (3)

A

CD19, CD20, kappa and lambda chains

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5
Q

T Cell markers (5)

A

CDIa, CD3, CD4/8, CD7, CD5

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6
Q

CD45

A

leukocyte common antigen

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7
Q

CD10

A

marker sometimes present on myeloid cells or B lymphoblasts

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8
Q

TdT

A

Present on immature lymphoid cells

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9
Q

CD15, CD30

A

markers of Hodgkin’s lymphoma

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10
Q

15, 17 translocation is associated with what?

A

Acute Myeloid Leukemia

Acute Promyelocytic Leukemia

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11
Q

9, 22 translocation is associated with what?

A

Chronic Myelogenous Leukemia

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12
Q

Mutations in these 3 genes that regulate hematopoiesis can give a survival advantage to mutated cells

A

FLT3, NPMI, JAK2

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13
Q

14, 18 translocation is associated with what?

A

Follicular Lymphoma

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14
Q

8, 14 translocation is associated with what?

A

Burkitt Lymphoma

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15
Q

11, 14 translocation is associated with what?

A

Mantle Cell Lymphoma

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16
Q

Fanconi anemia increases the risk for what?

A

Acute Leukemia

17
Q

Down Syndrome and Neurofibromatosis 1 increase the risk for what?

A

Childhood leukemias

18
Q

HTLV-1 virus is associated with what?

A

Adult T Cell Leukemia/ lymphoma

19
Q

HHV8 virus is associated with what?

A

Pleural Effusion Lymphoma

20
Q

Lymph node enlargement is

A

Lymphadenopathy

21
Q

Lymph node inflammation (typically tender) is

A

Lymphadenitis

22
Q

5 causes of lymphadenopathy

A

Infection, autoimmune disease, iatrogenic, malignancy and other factors (ex- sarcoidosis, dermatopathic lymphadenopathy)

23
Q

Aspirate bone marrow cells allow you to see what?

A

Individual cell morphology and number

24
Q

Features of Follicular Hyperplasia (4)

A
  1. Mantle Zone polarization
  2. Normal Bcl2 staining (mantle stains)
  3. Large germinal center
  4. Presence of Tingable body macrophages
25
Q

Features of Paracortical Hyperplasia (3)

A
  1. Paracortical (T cell area) expansion
  2. Histiocytes (macrophages) are present in sinuses
  3. Possible concurrent follicular hyperplasia
26
Q

Acute Nonspecific Lymphadenitis is characterized by

A

Enlarged, red, tender soft nodes

27
Q

What is the usual cause of acute nonspecific lymphadenitis and what demographic is typically involved

A

Kids- drainage infections
Teeth, tonsils –> cervical
Extremities, groin –> axillary/inguinal nodes
Appedicitis, yersinia –> mesenteric

28
Q

What is characteristic of Chronic Nonspecific Lymphadenitis and what is the cause?

A
  • Non-tender nodes presenting with any of the histological pattens
  • Caused by chronic immunologic stimulation
29
Q

Lymphomas typically present with

A

non-tender adenopathy (66%); 33% present with extranodal tissue involvement

30
Q

Leukemia symptoms

A

Symptoms of Bone Marrow Failure: poor clotting, bruising, petechia, anemia, more infections

31
Q

What is a plasma cell neoplasm?

A

Type of Lymphoid Neoplasm that involves terminally differentiated B cells that results in bony destruction (lytic lesions) and involved bone marrow

32
Q

General Symptoms of Lymphoma

A

lumps/bumps present for more than 2 months, hard lymph nodes, weight loss

33
Q

Differentiating Hodgkin and Non Hodgkin Lymphoma

A

HL- spreads in a systemic fashion

NHL- at diagnosis is more disseminated on a molecular level

34
Q

Diagnostic features that suggest lymphoid neoplasms (4)

A
  1. Loss of immune vigilance –> more infections
  2. Loss of immune tolerance –> autoimmunity
  3. Adenopathy that cannot be explained
  4. B Symptoms (fever, sweats, weight loss)

Disease and Therapeutics 1 (7 decks)

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