Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

Disease and Therapeutics 1 > Bones > Flashcards

Bones Flashcards

1
Q

Which cells have the RANK receptor?

A

Osteoclasts and Osteoclast Precursors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

What happens when RANKL binds the RANK receptor on Osteoclasts?

A

Binding stimulates survival and generation of Osteoclasts and increases NFKB (not for keeping bone)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is Osteoprotegrin?

A

Osteoprotegrin is produced by Stromal Cells or Osteoblasts and inhibites RANKL-RANK receptor interaction

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is M-CSF?

A

M-CSF is a cytokine produced by osteoblasts or stromal cells that results in the generation and survival of osteoclasts –> increased bone resorption and increased plasma Ca levels

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

What is the function of the WNT/Beta-Catenin Pathway?

A

WNT is produced from stromal cells and binds Osteoblasts (through LRP5 and LRP6) to increase secretion of Osteoprotegrin, blocking RANK-RANKL interaction**Note that a LOF mutation in LRP5/6 –> Osteoporosis and a GOF mutation in LRP5/6 –> Drastic increase in bone mass

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What is the main component of the bone’s organic matrix?

A

Type 1 Collagen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

What is Woven Bone?

A

Random Collagen deposition, pathologic, seen in rapid bone growth (ex-healing a fracture)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

What are the subtyes of Lamellar Bone? Describe its characteristics

A
  1. Compact Bone2. Spongy Bone-Stronger bone with ordered collagen deposition; replaces woven bone
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What will be increased with increased Osteoblast activity?

A

Osteopontin (osteocalcin) and Alkaline Phosphatase

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

RANK Ligand is located on which cells?

A

Osteoblasts and Marrow Stroma Cells

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

The end of a bone (distal to the growth plate) is the

A

Epiphysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

The area beneath the growth plate is call the

A

metaphysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

The central region of a long bone is the

A

Diaphysis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What is dystosis?

A

LOCAL problems in migration of mesenchyme and its condensationEx- bradydactyly because of HOXD13 defect

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

What is dysplasia?

A

GLOBAL defect in regulation of skeletal organogenesisEx- achondroplasia

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is the defect causing Cleidocranial Dysplasia and describe the symptoms

A

RUNX2 transcription factor defect-Short stature, abnormal clavicles, wormian bones, too many teeth

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

What is the cause of Achondroplasia?

A

FGFR3 mutation –> GOF that inhibits cartilage growth because of decreased chondrocyte proliferation in growth plates

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
18
Q

Continuation of appositional and intramembranous bone formation in Achondroplasia results in what?

A

Thick cortical bone

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
19
Q

What are the physical characteristics of Achondroplasia?

A

Short proximal limbs, normal trunk length, big forehead and head, depressed root of noseNormal life span, intelligence and reproductive status

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
20
Q

What is the cause of Thanatophoric Dwarfism and describe the symptoms

A

FGFR3 GOF mutation (same as Achondroplasia)-See short, bowed limbs, frontal bossing with macrocephaly, bell shaped chest (so respiratory failure) and CLOVERLEAF Skull

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
21
Q

What is Osteoporosis Pseudoglioma Syndrome?

A

Disease caused by LOF mutation of LRP5 that causes skeletal fragility and loss of vision

22
Q

What is the cause of Osteopetrosis (Marble Bone Disease)?

A

Disease of decreased osteoclast bone resorption caused by a defect in RANKL, LRP5 GOF mutation, or Carbonic Anhydrase II (CAII) deficiency (so cannot acidify pit)AD- benign, AR- malignant

23
Q

What are the clinical findings of Osteopetrosis?

A
  1. Extramedullary hematopoiesis –> hepatosplenomegaly2. Bulbous long bones (erlenmeyer flask deformity)3. Narrow neural foramina (mild cranial nerve defects)4. Brittle Bones, multiple fractures5. Mild anemia **TREAT- with Bone Marrow Transplant
24
Q

What is the cause of Osteogenisis Imperfecta?

A

Mutation in the alpha 1 or alpha 2 chains of TYPE 1 COLLAGEN

25
What are the clinical characteristics of Osteogenisis Imperfecta?
1. Brittle bones and multiple fractures (may decrease after puberty)2. Blue Sclerae3. Hearing Loss4. Loose joints
26
What are mucopolysaccharidoses?
Defects in enzymes degrading dermatan sulfate, heparan sulfate and keratan sulfate --> abnormal hyaline cartilage --> malformed bones
27
What are some potential causes of Osteoporosis?
1. Nutritional (lack of Ca)2. Menopause (increased RANK/RANKL expression --> increased osteoclast activity)3. Physical Activity (space flight)4. Aging (decreased replication of progenitor cells and synthetic activity of osteoblasts)5. Vitamin D Receptor Polymorphism6. Drugs, diabetes, malignancy, liver/ GI disease
28
What is osteoporosis?
A disease of decreased bone mass and increased porosity --> increased risk of fractures**May be described as osteopenia (decreased bone mass) to the point of risk for fracture
29
What determines most hereditary osteoporosis?
Vit D receptor, Collagen 1A1 and the Estrogen Receptor
30
How does decreased estrogen result in Osteoporosis in post-menopausal women?
Decreased Estrogen --> increased inflammatory cytokines that increase RANKL and decrease OPG**Estrogen replacement is effective treatment, but increases risk of breast cancer
31
What are common causes of secondary osteoporosis?
1. Hyperparathyroidism (most commonly caused by parathyroid adenoma)2. Neoplasia3. Multiple Myeloma4. Vit. D Defficiency (ricketts and osteomylasia)5. Anticoagulants6. Corticosteroids7. Immobilization
32
What is Dual-energy absorptiometry used for?
Detection of Osteoporosis
33
Describe the clinical features of Hyperparathyroidism
1. Increased osteoclast fxn --> subperiosteal resorption that thins the cortices2. Loss of lamina dura around teeth3. Bone loss on radial aspect of middle phalanges of index and middle finger4. General Osteopenia5. Brown Tumor- bone that is replaced by fibrovascular tissue (fractures will result in hemorrhage and you see granulation tissue and hemosiderin)
34
What is renal osteodystrophy?
-Altered OC/OB activity --> osteomalacia (delayed mineralization), osteosclerosis and osteoporosis-Hyperparathyroidism-Decreased activation of Vit D-Metabolic Acidosis
35
What are the stages of Paget's Disease?
1. Osteolytic Stage- loss of bone mass due to osteoclasts (see very thick cortex with "V shaped blade of grass" lesion2. Mixed Stage- Prominent Osteoblasts and Osteoclasts3. Osteosclerotic Stage- mosaic pattern of lamellar bone- jigsaw puzzle like cement lines
36
What is the important histological finding of Paget's Disease?
Bone mosaic with disorganized lamellae (look like swirls)
37
What are the clinical findings of Paget's Disease?
1. Pain from microfractures2. Increased Alkaline Phosphatase3. Normal Ca and PO44. Bone Overgrowth causing -Cranial Nerve Palsy -Heavy skull that is hard to hold up -Severe secondary osteoarthritis -Chalk stick-type fracture
38
Paget's Disease can cause what clinical problems?
1. High-output cardiac failure2. Tumors (benign and malignant)
39
What is used to treat Paget's Disease?
Calcitonin and Biphosphonates
40
Describe the order of healing after a fracture
Soft Tissue Callus (procallus) --> Boney CallusProcallus- hematoma/fibrin framework that activates osteoprogenitor cells; is not rigid and can be easily disruptedBoney Callus- made of woven bone +/- cartilage for enchondral ossification
41
What is avascular necrosis (osteonecrosis) and what are the common causes?
-Infarction of bone and marrow due to vessel injury; the dead bone/fat is replaced by Calcium Soaps-Causes: *Corticosteroids, infection, dysbarsim, pregnancy, sickle cell disease
42
What is a medullary infarct?
Subtype of avascular necrosis; can be small or large; large are painful (ex- dysbarism, sickle cell)
43
What is a Subchondral Infarct?
Subtype of avascular necrosis that results in a WEDGE SHAPED subchondral bone crack; secondary collapse may --> osteoarthritis
44
How would osteomyelitis appear on an X-Ray?
As a lytic bone lesion with surrounding sclerosis
45
What are the bacterial causes of osteomyelitis?
1. S aureus2. E coli, Pseudomonas, Klebsiella (infections of IV drug users)3. H flue and Group B Strep (infants)4. Salmonella (Sickle Cell Patients)
46
Describe the common locations for osteomyelitis for different age groups
1. Neonate- Metaphysis or Epiphysis2. Children- Metaphysis Adult- Epiphyses and subchondral bone
47
What is a Brodie Abscess?
A small intraosseous abscess often in the cortex walled off by reactive bone
48
What is Sclerosing Osteomyelitis of Garre
Osteomyelitis in the jaw with extensive new bone formation
49
A draining sinus of pyogenic osteomyelitis can develop into what?
Squamous Cell Carcinoma
50
What is the clinical characteristics of TB Osteomyelitis?
1. Occurs in immunosuppressed2. Pott's Disease: Lumbar and Thoracic Spine --> breaks through discs to other vertebrae --> scoliosis and kyphosis
51
What are the features of syphilis of the bone?
Saddle Nose and Saber Shin (tibia)

Disease and Therapeutics 1 (7 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions