Intro to the ANS Flashcards

1
Q

What would an increase in Arterial Baroreceptor firing lead to with regards to the ANS?

A

Stimulations of parasympathetic nerve; inhibits heart contraction

Inhibition of sympathetic innovation of heart and arteries to lower blood pressure and HR

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2
Q

Describe the balance of the ANS in the eye at rest:

A

Dominated by the Parasympathetic at rest.

You need your smooth muscle to be partially constricted so it can change in both directions

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3
Q

Where do parasympathetic nerves originate?

A

Cranial or Sacral regions

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4
Q

What is the neurotransmitter used in the Parasympathetic Nervous system?

A

ACh

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5
Q

What does the Preganglionic fibre of the SNS usually release?

A

ACh

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6
Q

What dies the Post-ganglionic fibre of the SNS usually release?

A

Noradrenaline

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7
Q

What post-ganglionic neurotransmitter may be secreted to innovate sweat glands?

A

ACh

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8
Q

What is the function of the SNS and PNS in the eye?

A

SNS: Pupil dilation

PNS: Constriction of pupil, Contraction of ciliary muscle

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9
Q

What is the balance of the ANS in the lungs at rest?

A

Dominated by the Parasympathetic;

There is a partial level of constriction so that it can both constrict further and dilate

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10
Q

What is the dominant branch of the ANS in the liver and what does it control?

A

Sympathetic

Glycogenolysis + Gluconeogenesis

You want glucose to be available in a fight or flight situation so sympathetic discharge will stimulate an increase in glycogenolysis and gluconeogenesis.

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11
Q

What are the effects of the SNS in the Kidneys, Bladder and Ureters?

A

Kidney: Increased renin secretion

Ureters and Bladder: Relaxes detrusor; constriction of trigone and sphincter

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12
Q

What are the effects of the ANS in the heart, and which is dominant at rest?

A

SNS: Increased rate and contractility

PNS: Decreased rate and contractility

PNS dominant at rest

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13
Q

Describe the ANS innovation of arteries and arterioles:

A

There is no parasympathetic innovation

The sympathetic is totally in control of the arterioles it controls constriction and dilation of the arterioles.

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14
Q

Where do the post-ganglionic neurones in the sympathetic limb project from, and what does this mean for their organisation?

A

Sympathetic trunk

Very divergent (1:20) neurones so the sympathetic responses are coordinated and divergent; because of the sympathetic trunk, there is a mass discharge of the SNS.

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15
Q

What are the consequences of the organisation and origins of the Parasympathetic trunk of the ANS?

A

Little divergence of neurones, so its effects tend to be discreet and localised.

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16
Q

Recall the organisation of the ANS and the neurotransmitters it uses:

A
17
Q

What are the two types of ACh receptor?

A

Nicotinic and Muscarinic

18
Q

Where are nicotinic receptors found?

A

At ALL autonomic ganglia

19
Q

What is the speed of Nicotinic receptors and why?

A

Rapid as they transfer the stimulus from the pre-ganglionic to the post-ganglionic neurone.

20
Q

What type of receptor is the Nicotinic receptor?

A

Type 1 - Ionotropic

21
Q

How do nicotinic receptors work?

A

Acetylcholine binds to the receptor and opens an ion channel that allows sodium/calcium influx and allows transmission.

22
Q

Where are Muscarinic receptors found?

A

At any tissue that is innervated by a post-ganglionic parasympathetic fibre

23
Q

What type of receptors are Muscarinic receptors?

A

Type 2 - G-protein coupled

24
Q

What is the speed of a muscarinic receptor?

A

Much slower than nicotinic

25
Q

What are the sub-types of Muscarinic receptors?

A
  • M1 – Neural (Forebrain – learning & memory)
  • M2 – Cardiac (Brain – inhibitory autoreceptors)
  • M3 – Exocrine & smooth muscle (Hypothalamus – food intake)
26
Q

Where are Adrenoceptors located?

A

Most effector organs innovated by post-ganglionic sympathetic fibres

27
Q

What type of receptors are adrenoceptors?

A

Type 2 - G-protein coupled

28
Q

What are the four types of Adrenoceptors?

A
  • Alpha 1
  • Alpha 2
  • Beta 1
  • Beta 2
29
Q

What are the functions of Alpha 1 and Beta 2 adrenoceptors, and what does this mean in terms of the ANS?

A

Alpha 1 Constricts

Beta 2 Dilates

  • The SNS controls vasculature by itself
30
Q

Describe the synthesis of ACh:

A

Acetyl CoA + Choline (from diet)

with Choline Acetyl Transferase

(within presynaptic bulb)

31
Q

Describe the metabolism of ACh:

A

Acetylcholinesterase converts ACh in the synapse to Choline and acetate. The Choline then reenters the bulb to from more ACh.

32
Q

What three enzymes are involved the biosynthesis of Noradrenaline, and what do they convert?

A

Tyrosine hydroxylase: Tyrosine to DOPA

DOPA decarboxylase: DOPA to Dopamine

Dopamine beta-hydroxylase: Dopamine to NA

33
Q

What is the main difference betweent he metabolism of ACh and NA?

A

NA is not metabolised in the synapse!

34
Q

How is noradrenaline removed from the synapse?

A

Uptake-1: Back into neuronal tissue

Uptake-2: into extraneuronal tissue

35
Q

How is NA metabolised, and where?

A

In neuronal tissue: Monoamine oxidase (MAO)

In extraneuronal tissue: Catechol-O-Methyl Transferase (COMT)